Prognostic role of human papilloma virus status in hypopharyngeal squamous cell carcinoma.
Prognostic role of human papilloma virus status in hypopharyngeal squamous cell carcinoma.
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DOI：
10.1002/lio2.443
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发表时间：
2020-10
影响因子：
1.9
通讯作者：
Sigel K
中科院分区：
文献类型：
--
作者：
Marshall DC;Kao DD;Bakst R;Sharma S;Ferrandino R;Rosenzweig K;Wisnivesky J;Sigel K
虽然人类乳头瘤病毒(HPV)状态在口咽头颈部鳞状细胞癌(SCC)中的预后作用已得到证实，但越来越多的证据表明，HPV状态可能在下咽SCC中具有预后作用。本研究的目的是确定HPV状态在下咽鳞状细胞癌中的预后作用。我们对2010-2016年间确诊的1934名成年HNSCC患者进行了基于人群的回顾性分析，这些患者接受了手术和/或放射治疗的联合治疗，其中包括641名下咽鳞状细胞癌患者和已知HPV状态的患者，这些患者包括在HPV状态数据库中的监测、流行病学和最终结果(SEER)头部和颈部。患者数据被用来确定整个队列和已知HPV状态的特定亚组下咽癌患者的调整后2年癌症特异性生存期(CSS)和总生存期(OS)。在1934例下咽鳞状细胞癌中，HPV状态不明者1294例(66.9%)，HPV阳性167例(8.6%)，在已知HPV状态的下咽鳞状细胞癌中，21.6%为HPV阳性。在对性别、年龄、种族/民族、婚姻状况和阶段进行调整的模型中，与HPV阴性肿瘤患者相比，HPV阳性下咽肿瘤患者的生活质量得到改善(Css：HR：.57，95%CI=.38至.86，P= .008；OS：HR：.49，95%CI=.34至.71，P= <；.001)。我们在已知HPV状态和癌症特异性存活率的大量下咽鳞状细胞癌队列中的发现支持了HPV在下咽癌中具有预后作用的假设。应考虑增加下咽鳞状细胞癌的HPV检测。4我们进行了一项基于人群的分析，以确定641名下咽鳞状细胞癌患者的调整后2年癌症特异性生存率和总体生存率，这些患者的HPV状态包括在HPV状态数据库的监测、流行病学和最终结果中。在调整了性别、年龄、种族/民族、婚姻状况和阶段的模型中，与HPV阴性的肿瘤患者相比，HPV阳性的下咽肿瘤患者的生活质量得到了改善(Css：HR：.57，95%CI=.38至.86，P=.008；OS：HR：.49，95%CI=.34至.71，P= <； .001)，这支持了HPV对下咽癌有预后作用的假设。应考虑增加对下咽HNSCC的HPV检测。
Although the prognostic role of human papilloma virus (HPV) status in oropharyngeal head and neck squamous cell carcinoma (SCC) is well established, growing evidence shows that there may be a prognostic role for HPV status in hypopharyngeal SCC. The objective of this study was to determine the prognostic role of HPV status in hypopharyngeal SCC. We performed a retrospective, population‐based analysis of 1934 adult patients with HNSCC diagnosed between 2010‐2016 and treated with a combination of surgery and/or radiotherapy, with or without chemotherapy, and a subset of 641 patients with hypopharyngeal SCC and known HPV status included in the Surveillance, Epidemiology, and End Results (SEER) Head and Neck with HPV Status Database. Patient data were used to determine the adjusted 2‐year cancer‐specific survival (CSS) and overall survival (OS) for the entire cohort and the specific subgroup of hypopharyngeal cancer patients with known HPV status. Of the 1934 hypopharynx SCC cases, HPV status was unknown in 1294 (66.9%), and 167 (8.6%) were HPV positive; among hypopharynx cases with known HPV status, 21.6% were HPV positive. In models adjusting for sex, age, race/ethnicity, marital status and stage, patients with HPV‐positive hypopharyngeal tumors had improved CSS compared with patients with HPV‐negative tumors (CSS: HR: .57, 95% CI = .38 to .86, P = .008; OS: HR: .49, 95% CI = .34 to .71, P = <.001). Our findings in a large cohort of hypopharyngeal SCC with known HPV status and cancer‐specific survival support the hypothesis that HPV has a prognostic role in hypopharyngeal cancer. Consideration should be given to increased testing for HPV in hypopharyngeal SCC. 4 We performed a population‐based analysis to determine the adjusted 2‐year cancer‐specific survival and overall survival of 641 patients with hypopharyngeal SCC and known HPV status included in the Surveillance, Epidemiology, and End Results Head and Neck with HPV Status Database. In models adjusting for sex, age, race/ethnicity, marital status and stage, patients with HPV‐positive hypopharyngeal tumors had improved CSS compared with patients with HPV‐negative tumors (CSS: HR: .57, 95% CI=.38 to .86, P=.008; OS: HR: .49, 95% CI=.34 to .71, P= < .001), which supports the hypothesis that HPV has a prognostic role hypopharyngeal cancer. Consideration should be given to increased testing for HPV in hypopharyngeal HNSCC.
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DOI：
10.15761/ohns.1000160
发表时间：
2018
期刊：
Otorhinolaryngology-head and neck surgery
影响因子：
--
作者：
Burr AR;Harari PM;Ko HC;Chen S;Yu M;Baschnagel AM;Kimple RJ;Witek ME
通讯作者：
Witek ME
影响因子：
168.9
作者：
Mehanna, Hisham;Robinson, Max;Dunn, Janet
通讯作者：
Dunn, Janet
影响因子：
8.9
作者：
Marur, Shanthi;Forastiere, Arlene A.
通讯作者：
Forastiere, Arlene A.
影响因子：
4.8
作者：
Hughes, Ryan T.;Beuerlein, William J.;Greven, Kathryn M.
通讯作者：
Greven, Kathryn M.
影响因子：
168.9
作者：
Gillison, Maura L.;Trotti, Andy M.;Quynh Thu Le
通讯作者：
Quynh Thu Le