Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: Evidence for compartmentalization of HIV-1 between semen and blood
Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: Evidence for compartmentalization of HIV-1 between semen and blood
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DOI：
10.1086/514213
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发表时间：
1998-02-01
影响因子：
6.4
通讯作者：
Krieger, JN
中科院分区：
文献类型：
--
作者：
Coombs, RW;Speck, CE;Krieger, JN
对128名感染人类免疫缺陷病毒1型（HIV-1）的男性进行了血液和生殖器间质的定性和定量病毒学测量，以解决有关HIV-1在精液中脱落的几个有争议的问题，并获得有关这两个间质之间病毒分布的进一步信息，早期的研究表明，血液和精液中的病毒载量、表型和基因型之间的相关性很差，这表明病毒存在区室化。精液和血液之间的以下观察结果进一步支持了这种病毒区室化：精液中病毒的可培养性与血液中病毒RNA水平之间缺乏相关性，病毒表型的不一致分布，不一致的病毒RNA水平，精液中病毒RNA水平与血液中CD 4细胞计数之间的弱相关性，病毒RNA水平的生物变异性差异，以及抗逆转录病毒治疗对病毒载量反应的差异。
Both qualitative and quantitative virologic measurements were compared between blood and genital compartments for 128 men infected with human immunodeficiency virus type 1 (HIV-1) to address several controversial issues concerning HIV-1 shedding in semen and to obtain further information about the distribution of virus between these two compartments, Evidence for viral compartmentalization was suggested by earlier studies that noted the poor correlation between blood and seminal virus load, phenotype, and genotype. Further support for this viral compartmentalization was based on the following observations between semen and blood: lack of association between culturability of virus in semen and viral RNA level in blood, discordant distribution of viral phenotypes, discordant viral RNA levels, a weak correlation between viral RNA level in semen and CD4 cell count in blood, differences in the biologic variability of viral RNA levels, and differences in the virus load response to antiretroviral therapy.