Recent advances in the structure and assembly of the archaeal flagellum
Recent advances in the structure and assembly of the archaeal flagellum
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DOI：
10.1159/000077868
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发表时间：
2004-01-01
影响因子：
1.2
通讯作者：
Jarrell, KF
中科院分区：
文献类型：
--
作者：
Bardy, S;Ng, SYM;Jarrell, KF
古细菌运动是通过鞭毛的旋转而发生的，鞭毛与细菌上的鞭毛不同。这两种结构之间的差异包括古细丝的多链蛋白质性质，鞭毛蛋白的广泛翻译后修饰以及每个鞭毛蛋白上的短信号肽在每个鞭毛蛋白上被特定信号肽裂解，然后在成熟之前掺入特定的信号肽酶鞭毛进入鞭毛丝。研究揭示了古细菌鞭毛与IV型菌毛之间的相似性，包括在鞭毛蛋白和pilin上存在相似的异常信号肽，主要结构蛋白本身的氨基酸序列中的相似性以及潜在组装和处理之间的相似性成分。最近的建议是IV pili是细胞表面复合物系列的一部分，再加上IV pili型和古细菌鞭毛之间的相似性，引发了有关这些系统演变的问题，并可能将古细菌鞭毛包含在这个表面复合物中。版权（C）2004 S. Karger AG，巴塞尔。
Archaeal motility occurs through the rotation of flagella that are distinct from the flagella found on bacteria. The differences between the two structures include the multi-flagellin nature of the archaeal filament, the widespread posttranslational modification of the flagellins and the presence of a short signal peptide on each flagellin that is cleaved by a specific signal peptidase prior to the incorporation of the mature flagellin into the flagellar filament. Research has revealed similarities between the archaeal flagellum and the type IV pilus, including the presence of similar unusual signal peptides on the flagellins and pilins, similarities in the amino acid sequences of the major structural proteins themselves, as well as similarities between potential assembly and processing components. The recent suggestion that type IV pili are part of a family of cell surface complexes, coupled with the similarities between type IV pili and archaeal flagella, raise questions about the evolution of these systems and possible inclusion of archaeal flagella into this surface complex family. Copyright (C) 2004 S. Karger AG, Basel.