Comparison of retinal nerve fibre layer thickness measurements calculated by the optic nerve head map (NHM4) and RNFL3.45 modes of spectral-domain optical coherence tomography (RTVue-100)
Comparison of retinal nerve fibre layer thickness measurements calculated by the optic nerve head map (NHM4) and RNFL3.45 modes of spectral-domain optical coherence tomography (RTVue-100)
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DOI：
10.1136/bjo.2009.166314
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发表时间：
2010-06-01
影响因子：
4.1
通讯作者：
Kook, Michael S.
中科院分区：
文献类型：
--
作者：
Shin, Chul Jin;Sung, Kyung Rim;Kook, Michael S.
目的评价和比较直接扫描法测量视网膜神经纤维层（RNFL）厚度（RNFL3.45模式）和从数据集重新采样方法采用光学相干断层扫描仪（OCT）对36例正常人和76例青光眼患者进行Stratus OCT成像（快速RNFL模式，RNFL 3）和RTVue-100 OCT（NHM 4（RNFL 1）和RNFL3.45（RNFL 2）模式）。在RTVue-100 OCT的NHM 4和RNFL 3.45模式下评估测量再现性（组内相关系数（ICC））。不同RNFL测量值之间的一致性通过Bland-Altman图进行分析。结果NHM 4和RNFL 3.45两种测量模式均具有良好的测量重复性（ICC 0.831-0.978）。RTVue-100 OCT的两种不同模式和Stratus OCT的RNFL厚度在所有扇区（包括平均值）中相关。RNFL 1和RNFL 2数据之间没有显著差异。然而，RNFL厚度在青光眼眼的RTVue-100 OCT显着大于测量的Stratus OCT。RNFL厚度确定的两种不同模式的RTVue-100 OCT是在极好的协议（95%的协议限制-6.53至6.95 μ m）。3种RNFL测量方法均具有良好的青光眼识别能力（AUC = RNFL 1 0.970、RNFL 2 0.962、RNFL 3 0.971）。结论直接扫描法和重新采样法测量的RNFL厚度具有良好的一致性。然而，这两个测量结果在昏迷的受试者与Stratus OCT显着不同。这些结果应考虑当一个病人是后续使用不同类型的OCT。
Aim To evaluate and compare retinal nerve fibre layer (RNFL) thickness measured by direct scanning (RNFL3.45 mode) and re-sampling from datasets (NHM4 mode) of RTVue-100 optical coherence tomography (OCT).Methods Thirty-six healthy subjects and 76 subjects with glaucoma were imaged with Stratus OCT (fast RNFL mode, RNFL3) and RTVue-100 OCT (NHM4 (RNFL1) and RNFL3.45 (RNFL2) modes). Measurement reproducibility was assessed in NHM4 and RNFL3.45 modes of RTVue-100 OCT (intraclass correlation coefficient (ICC)). Agreement between different RNFL measurements was analysed by Bland-Altman plot. The areas under the receiver operating characteristic (ROC) curves (AUCs) for discrimination between healthy and glaucoma were compared between the different RNFL measurements.Results Both NHM4 and RNFL3.45 modes showed excellent measurement reproducibilities (ICC 0.831-0.978). RNFL thicknesses by two different modes of the RTVue-100 OCT, and by the Stratus OCT, were correlated in all sectors, including average. There was no significant difference between RNFL1 and RNFL2 data. However, RNFL thickness in glaucomatous eyes by the RTVue-100 OCT was significantly greater than that measured by Stratus OCT. RNFL thicknesses determined by the two different modes of RTVue-100 OCT were in excellent agreement (95% limits of agreement -6.53 to 6.95 mu m). All three RNFL measurements showed good glaucoma discrimination ability (AUC = RNFL1 0.970, RNFL2 0.962, RNFL3 0.971).Conclusions RNFL thickness determined by direct scanning and re-sampling from datasets of RTVue-100 OCT were in good agreement. However, both measurements in glaucomatous subjects were significantly different from those with the Stratus OCT. Those findings should be considered when a patient is followed-up using different types of OCT.