Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation exposure to inhaled manganese sulfate
Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation exposure to inhaled manganese sulfate
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DOI：
10.1093/toxsci/kfi060
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发表时间：
2005-03-01
影响因子：
3.8
通讯作者：
Wong, BA
中科院分区：
文献类型：
--
作者：
Dorman, DC;McElveen, AM;Wong, BA
有关吸入后锰在新生儿体内的组织分布的信息很少。本研究测定了雾化吸入硫酸锰(MnSO4)后哺乳期Cd大鼠及其子代组织中的锰浓度。除分娩期间外，母鼠及其后代从繁殖前28天开始，每周暴露于空气或MnSO4(0.05、0.5或1 mg Mn/m(3))中，每天6小时，每周7天，直到出生后第18天。尽管母体组织中的锰浓度有所增加，但吸入MnSO4并不影响母鼠的体重增加、末期(PND 18)体重或器官重量。暴露于1 mg Mn/m(3)的MnSO4可导致PND 19和部分PND 14-PND 45幼鼠的体重下降。暴露于0.05 mg Mn/m(3)的MnSO4与PND 1仔鼠的胃内容物、血液、肝脏和头盖骨中的锰浓度升高，PND 14仔鼠的脑、肺和股骨中的锰浓度升高，以及PND 19仔鼠的嗅球、小脑和纹状体中的锰浓度升高有关。与对照组相比，暴露于大于或等于0.5 mg Mn/m(3)的MnSO4增加了PND 14只仔鼠的肝脏和血液中的锰浓度，并增加了PND 19只仔鼠的肝脏、胰腺和股骨中的锰浓度。所有子代组织中的锰浓度通过PND 45+/-1恢复到控制值。我们的数据表明，吸入MnSO4后观察到的新生儿组织中的锰浓度取决于MnSO4暴露浓度和动物的年龄。
There is little information regarding the tissue distribution of manganese in neonates following inhalation. This study determined tissue manganese concentrations in lactating CD rats and their offspring following manganese sulfate (MnSO4) aerosol inhalation. Except for the period of parturition, dams and their offspring were exposed to air or MnSO4 (0.05, 0.5, or 1 mg Mn/m(3)) for 6 h/day, 7 days/week starting 28 days prior to breeding through postnatal day (PND) 18. Despite increased manganese concentrations in several maternal tissues, MnSO4 inhalation exposure did not affect body weight gain, terminal ( PND 18) body weight, or organ weights in the dams. Exposure to MnSO4 at 1 mg Mn/m(3) resulted in decreased pup body weights on PND 19 and decreased brain weights in some PND 14 to PND 45 pups. Exposure to MnSO4 at similar to 0.05 mg Mn/m(3) was associated with increased stomach content, blood, liver, and skull cap manganese concentrations in PND 1 pups, increased brain, lung, and femur manganese concentrations in PND 14 pups, and elevated olfactory bulb, cerebellum, and striatum manganese concentrations in PND 19 pups. When compared to controls, MnSO4 exposure to greater than or equal to 0.5 mg Mn/m(3) increased liver and blood manganese concentrations in PND 14 pups and increased liver, pancreas, and femur manganese concentrations in PND 19 pups. Manganese concentrations returned to control values in all offspring tissues by PND 45 +/- 1. Our data demonstrate that neonatal tissue manganese concentrations observed following MnSO4 inhalation are dependent on the MnSO4 exposure concentration and the age of the animal.