Evolutionary tuning knobs
Evolutionary tuning knobs
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DOI：
10.1016/s0160-9327(97)01005-3
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发表时间：
1997-01-01
期刊：
影响因子：
0.6
通讯作者：
Kashi, Y
中科院分区：
文献类型：
--
作者：
King, DG;Soller, M;Kashi, Y
自发突变是进化所依赖的所有自然遗传变异的最终来源，最近的观察表明，许多基因都与易突变的DNA区域相关，每个DNA区域都由一个简单的基序重复组成。这些简单序列重复序列(SSR)可能提供一个以前未被认识到的丰富数量遗传变异的来源，这些突变是频繁的、特定于位置的和可逆的，但很少具有实质性有害的突变，这些序列可能在进化上具有重要意义，为基因组和单个基因配备可调节的“调节旋钮”，以进行有效的适应。
Spontaneous mutations are the ultimate source of all natural genetic variation upon which evolution depends, Recent observations have revealed that many genes are associated with mutation-prone DNA tracts, each consisting of a simple motif repeated over and over in tandem. These simple sequence repeats (SSRs) may provide a previously unrecognized source of abundant quantitative genetic variation based on mutations that are frequent, site-specific and reversible, yet seldom substantially deleterious, Such sequences may be evolutionarily significant, equipping genomes and individual genes with adjustable 'tuning knobs' for efficient adaptation.