Thermoregulation.
Thermoregulation.
复制标题
体温调节。
DOI：
10.1152/ajpregu.00571.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
DiBona,GeraldF
中科院分区：
文献类型：
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作者：
DiBona,GeraldF
体温调节是一个主题，清楚地反映了该杂志标题的调节，综合和比较部分。体温是通过许多机制的整合来密切调节的，这些机制的研究得到了比较生理学的极大帮助。地松鼠，无论是金背松鼠（8，15，20）、十三纹松鼠（2）还是北极松鼠（4，18），都被认为是研究睡眠、觉醒、唤醒和麻木期间体温调节的生物化学、代谢和免疫学方面的合适对象。对灰鼠狐猴（14）、小棕蝠（7）和高山旱獭（12）冬眠期间体温调节和能量周转的研究也已开展。对肥胖Zucker大鼠（瘦素受体基因突变并表达功能失调的瘦素受体）的体温调节、发热信号和禁食代谢反应之间的复杂关系进行了研究。肥胖Zucker大鼠的体核温度（T B）低于瘦Zucker大鼠。一项研究（9）检查了这是否是由于体温调节缺陷或T B设定点向下重置的结果。肥胖Zucker大鼠T B和氧消耗量低于瘦Zucker大鼠。此外，肥胖的Zucker大鼠选择比瘦的Zucker大鼠占据温度梯度（Ta：15-35 ℃）中较冷的环境温度（Ta）。这表明肥胖Zucker大鼠的T B设定点较低，因为它们拒绝选择更温暖的T a，这可能使它们能够抵消导致低T B的任何体温调节缺陷。
thermoregulation is a subject that clearly reflects the regulatory, integrative, and comparative portions of the journal's title. Body temperature is closely regulated via the integration of a number of mechanisms whose study has been greatly assisted by exploitation of comparative physiology. Ground squirrels, be they golden mantled (8, 15, 20), thirteen lined (2), or Arctic (4, 18), have all been found to be suitable subjects for the study of the biochemical, metabolic, and immunological aspects of temperature regulation during sleep, wakefulness, arousal, and torpor. Studies of temperature regulation and energy turnover have also been conducted during hibernation in the gray mouse lemur (14), little brown bat (7), and Alpine marmot (12).The complex relationship between body temperature regulation, febrigenic signaling, and metabolic responses to fasting has been examined in the fatty Zucker rat, which has a mutation in the leptin receptor gene and expresses a dysfunctional leptin receptor. Fatty Zucker rats have a body core temperature (T b) that is below that of lean Zucker rats. One study (9) examined whether this was due to a result of deficits in thermoregulation or a downward resetting of the set point for T b. Fatty Zucker rats had lower T b and oxygen consumption than lean Zucker rats. In addition, fatty Zucker rats chose to occupy a cooler ambient temperature (T a) in a thermal gradient (T a: 15–35 C) than lean Zucker rats. This indicates a lower set point for T b in the fatty Zucker rats as they refused the option to select a warmer T a that might allow them to counteract any thermoregulatory deficiency that leads to a low T b.