Oat bran beta-glucan improves glucose homeostasis in mice fed on a high-fat diet
Oat bran beta-glucan improves glucose homeostasis in mice fed on a high-fat diet
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燕麦麸β-葡聚糖可改善高脂饮食小鼠的葡萄糖稳态
DOI：
10.1039/c7ra10437e
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发表时间：
2017
期刊：
影响因子：
3.9
通讯作者：
Zhang GY
中科院分区：
文献类型：
--
作者：
Cheng Yuliang;Zhang Jie;Luo Kaiyun;Zhang Genyi;Zhang GY
燕麦类功能食品通常采用富含1,3-β-D-葡聚糖的燕麦麸皮生产，其中β-葡聚糖（称为燕麦麸β-葡聚糖（OB-β-glucan））不仅与多种其他食品成分共存，而且与提取的β-葡聚糖以不同的物理形态存在。在当前的研究中，研究了 OB-β-葡聚糖对高脂饮食小鼠葡萄糖稳态的影响，以确定与提取的 β-葡聚糖相比，燕麦麸是否提供额外的功能性代谢作用。使用C57BL/6J小鼠模型进行的实验结果表明，与低脂饮食（LF）喂养的小鼠相比，治疗六周后，高脂（HF）饮食治疗的小鼠体重（25.1%）、空腹血糖（17.4%）、糖化血红蛋白（HbA1c）（31.6%）和胰岛素抵抗显着增加。相比之下，OB-β-葡聚糖及其在 HF 饮食中含有相同量 β-葡聚糖 (4%) 的提取物均显着提高了胰岛素敏感性，同时降低了 HbA1c 水平和体重增加。肝葡萄糖激酶 (GK) 和肠磷酸烯醇丙酮酸羧激酶 (PEPCK) 的激活，以及神经肽阿黑皮素原 (POMC) 与神经肽 Y (NPY) 的比例增加，表明在用 OB-β-葡聚糖或其提取的对应物治疗后，肠-肝-脑轴机制可改善胰岛素敏感性和葡萄糖稳态。总之，OB-β-葡聚糖，即使是不同的物理形式，与提取的β-葡聚糖相比也发挥相似的生理作用，并且β-葡聚糖是燕麦麸对葡萄糖稳态的健康影响的主要功能成分。
Oat-based functional foods are commonly produced with 1,3-β-D-glucan-enriched oat bran in which β-glucan (termed as oat bran β-glucan (OB-β-glucan)) not only co-exists with multiple other food components but also exists in different physical forms compared to extracted β-glucan. In the current study, the impacts of OB-β-glucan on the glucose homeostasis of mice fed on a high-fat diet were investigated to determine whether oat bran provided additional functional metabolic effects compared to extracted β-glucan. The experimental results using a C57BL/6J mouse model showed that high-fat (HF) diet treatment significantly increased the body weight (25.1%), fasting blood glucose (17.4%), glycated hemoglobin (HbA1c) (31.6%) and insulin resistance when compared to mice fed on a low fat diet (LF) after treatment for six weeks. In contrast, both OB-β-glucan and its extracted counterpart with the same amount of β-glucan (4%) in the HF-diet significantly improved the insulin sensitivity with reduced levels of HbA1c and body weight gain. The activation of liver glucokinase (GK) and intestinal phosphoenolpyruvate carboxykinase (PEPCK), and an increased ratio of neuro-peptide proopiomelanocortin (POMC) to neuropeptide Y (NPY) suggest a gut–liver–brain axis mechanism to improved insulin sensitivity and glucose homeostasis after treatment by either OB-β-glucan or its extracted counterpart. In conclusion, OB-β-glucan, even in a different physical form, exerted similar physiological effects compared to extracted β-glucan, and the β-glucan is the predominant functional component in the health effects of oat bran on glucose homeostasis.