Chronic low-lead exposure from birth produces deficits in discrimination reversal in monkeys.
Chronic low-lead exposure from birth produces deficits in discrimination reversal in monkeys.
复制标题
从出生起长期接触低铅会导致猴子的歧视逆转出现缺陷。
DOI：
10.1016/0041-008x(85)90319-9
复制
发表时间：
1985
影响因子：
3.8
通讯作者：
Deborah C. Rice
中科院分区：
文献类型：
--
作者：
Deborah C. Rice
Cynomolgus monkeys (Macaca fascicularis) were dosed from birth with 100, 50, or 0 μg/kg/day of lead. This protocol resulted in blood lead concentrations of 25, 15, or 3 μg/dl, respectively, before withdrawal of infant formula at 200 days of age. Blood lead concentration declined thereafter over the next 100 to 150 days to steady-state levels of 13, 11, or 3 μg/dl. At approximately 3 years of age, monkeys were tested on a series of three discrimination reversal tasks: nonspatial form discrimination, nonspatial color discrimination with irrelevant form cues, and nonspatial form discrimination with irrelevant color cues. The higher dose group was impaired relative to controls over the entire experiment (all three tasks combined), the two form discrimination tasks combined, and the form discrimination with no irrelevant cues. Deficits were most marked over the first several reversals. The lower dose group was impaired on the color discrimination task and on the last several reversals of all tasks combined. In addition, the higher dose group was impaired relative to the lower dose group over the entire experiment.
喜马拉雅偏远地区人群的血铅浓度。
DOI：
10.1126/science.7444442
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Piomelli,S;Corash,L;Corash,MB;Seaman,C;Mushak,P;Glover,B;Padgett,R
通讯作者：
Padgett,R
DOI：
10.1073/pnas.79.10.3335
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
PIOMELLI, S;SEAMAN, C;DAVIDOW, B
通讯作者：
DAVIDOW, B