Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum.
Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum.
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DOI：
10.1021/np5002253
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发表时间：
2014-06-27
影响因子：
5.1
通讯作者：
Cichewicz, Robert H.
中科院分区：
文献类型：
--
作者：
Du, Lin;Robles, Andrew J.;King, Jarrod B.;Mooberry, Susan L.;Cichewicz, Robert H.
Two new dimeric epipolythiodiketopiperazines, preussiadins A (1) and B (2), together with two known diastereomers, leptosins C (6) and A (7), were obtained from the mycelia of a Preussia typharum isolate. The structures of the new compounds were established by spectroscopic methods, and the absolute configurations of 1 and 2 were assigned by chemical transformations and comparisons of quantum chemical ECD and VCD calculations to experimental data. Compound 1 exhibited potent cytotoxic activity in the NCI-60 cell line panel with an average LC50 value of 251 nM. Further studies demonstrated that 1 circumvents P-glycoprotein-mediated drug resistance, yet had no significant antitumor activity in a xenograft UACC-62 melanoma model.
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影响因子：
11.2
作者：
Risinger AL;Jackson EM;Polin LA;Helms GL;LeBoeuf DA;Joe PA;Hopper-Borge E;Ludueña RF;Kruh GD;Mooberry SL
通讯作者：
Mooberry SL
影响因子：
15
作者：
Iwasa, Eriko;Hamashima, Yoshitaka;Sodeoka, Mikiko
通讯作者：
Sodeoka, Mikiko
影响因子：
5.8
作者：
GHAREHBAGHI, K;SREENATH, A;JAYARAM, HN
通讯作者：
JAYARAM, HN
影响因子：
3.7
作者：
Rether, Jan;Serwe, Annegret;Erkel, Gerhard
通讯作者：
Erkel, Gerhard
影响因子：
3.7
作者：
Biddanda, BA;Cotner, JB
通讯作者：
Cotner, JB