New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders.
New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders.
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DOI：
10.3390/medicines5040107
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发表时间：
2018-10-02
期刊：
影响因子：
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通讯作者：
Fadda, Paola
中科院分区：
文献类型：
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作者：
Scherma, Maria;Masia, Paolo;Fadda, Paola
随着内源性大麻素系统及其作为各种病理疾病治疗靶点的潜力的发现，研究人员越来越感兴趣地研究大麻及其衍生物在医疗用途中的作用。化合物 Delta9-四氢大麻酚和大麻二酚是大麻提取物中发现的最丰富的植物大麻素，也是研究最多的。本综述旨在概述其在治疗精神疾病（包括精神分裂症、焦虑症和抑郁症）方面的有益作用的当前证据。然而，需要进一步调查来澄清许多悬而未决的问题，特别是那些与使用大麻用于治疗目的时的效益和风险评估有关的问题，从而也有助于国家和联邦司法管辖区保持最新状态。
Following the discovery of the endocannabinoid system and its potential as a therapeutic target for various pathological conditions, growing interest led researchers to investigate the role of cannabis and its derivatives for medical purposes. The compounds Delta9-tetrahydrocannabinol and cannabidiol are the most abundant phytocannabinoids found in cannabis extracts, as well as the most studied. The present review aims to provide an overview of the current evidence for their beneficial effects in treating psychiatric disorders, including schizophrenia, anxiety, and depression. Nevertheless, further investigations are required to clarify many pending issues, especially those relative to the assessment of benefits and risks when using cannabis for therapeutic purposes, thereby also helping national and federal jurisdictions to remain updated.