Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements.
Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements.
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DOI：
10.1523/jneurosci.2515-11.2011
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发表时间：
2011-09-07
期刊：
影响因子：
--
通讯作者：
Lisberger SG
中科院分区：
文献类型：
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作者：
Li JX;Medina JF;Frank LM;Lisberger SG
我们已经评估了神经学习的出现，在额叶眼场（FEFSEM）和絮状复合体的小脑，而猴子学会了一个精确的时间变化的方向追求眼球运动。对于每个神经元，我们测量了整个学习过程中神经反应变化的时间过程，其中包括至少100次重复的目标方向的指导性变化。在这两个领域，平均人群学习曲线以高保真度跟踪行为变化，与驾驶学习中可能的角色一致。然而，单个神经元的学习曲线有时与行为学习的平滑、单调的进展关系不大。在FEFSEM中，神经学习是情节性的。对于单个神经元，学习在学习过程中的不同时间出现，有时在学习结束时消失。不同的FEFSEM神经元表达最大的学习在不同的时间相对于收购的行为学习。在絮状复合体中，许多浦肯野细胞根据与行为学习相同的时间过程获得了学习的简单棘波反应，并在整个学习过程中保留了它们的学习反应。少数浦肯野细胞在学习阶段后期获得了学习反应，在行为学习达到渐近线之后。我们的结论是，在单个神经元的学习可以遵循一个非常不同的时间过程从行为学习。FEFSEM和絮状复合体都包含学习的多个时间分量的表示，在学习运动的获取过程中，不同的神经元在不同的时间对学习做出贡献。
We have evaluated the emergence of neural learning in the frontal eye fields (FEFSEM) and the floccular complex of the cerebellum while monkeys learned a precisely-timed change in the direction of pursuit eye movement. For each neuron, we measured the time course of changes in neural response across a learning session that comprised at least 100 repetitions of an instructive change in target direction. In both areas, the average population learning curves tracked the behavioral changes with high fidelity, consistent with possible roles in driving learning. However, the learning curves of individual neurons sometimes bore little relation to the smooth, monotonic progression of behavioral learning. In the FEFSEM, neural learning was episodic. For individual neurons, learning appeared at different times during the learning session and sometimes disappeared by the end of the session. Different FEFSEM neurons expressed maximal learning at different times relative to the acquisition of behavioral learning. In the floccular complex, many Purkinje cells acquired learned simple-spike responses according to the same time course as behavioral learning and retained their learned responses throughout the learning session. A minority of Purkinje cells acquired learned responses late in the learning session, after behavioral learning had reached an asymptote. We conclude that learning in single neurons can follow a very different time course from behavioral learning. Both the FEFSEM and the floccular complex contain representations of multiple temporal components of learning, with different neurons contributing to learning at different times during the acquisition of a learned movement.