Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei
Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei
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DOI：
10.1021/acs.jnatprod.5b00555
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发表时间：
2016-02-01
影响因子：
5.1
通讯作者：
Sugawara, Fumio
中科院分区：
文献类型：
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作者：
Nishikori, Shu;Takemoto, Kenji;Sugawara, Fumio
从赫奎青霉（Penicillium herquei）的真菌培养液中分离得到了新的二氮杂双环[2.2.2]辛烷衍生物，青霉喹酰胺（peniciherquamides）A-C（1-3）和新赫奎酮（neoherqueinone）（5）。这些新化合物的结构通过光谱数据（1D/2D NMR、MS和IR）的解释来确定。同时还分离得到4个已知化合物，分别为阿伐他汀（4）、青霉Herqueinone（6）和Herqueinone/isoherqueinone（7/7a）。测试分离的化合物的抗丙型肝炎病毒（HCV）活性，发现青霉喹酰胺C（3）显示出5.1 μ M的IC 50值。据我们所知，这是第一个具有抗CV活性的二氮杂双环[2.2.2]辛烷衍生物的报道。
New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A-C (1-3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinone/isoherqueinone (7/7a), were also obtained. The isolated compounds were tested for anti hepatitis C virus (HCV) activity, and peniciherquamide C (3) was found to display an IC50 value of 5.1 mu M. To our knowledge, this is the first report of a diazabicyclo[2.2.2]octane derivative with anti-CV activity.