Engineering natural matrices with black phosphorus nanosheets to generate multi-functional therapeutic nanocomposite hydrogels
Engineering natural matrices with black phosphorus nanosheets to generate multi-functional therapeutic nanocomposite hydrogels
复制标题
用黑磷纳米片改造天然基质以生成多功能治疗性纳米复合水凝胶
DOI：
10.1039/c9bm01072f
复制
发表时间：
2019-10-01
影响因子：
6.6
通讯作者：
Wang, Yingjun
中科院分区：
文献类型：
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作者：
Miao, Yali;Shi, Xuetao;Wang, Yingjun
天然多糖和蛋白质具有良好的生物相容性和生物可降解性，已被广泛用于制备水凝胶基质。然而，通过方便的功能化策略实现亲水基质的多种功能是具有挑战性的。在本文中，我们报告了以黑磷（BP）纳米片作为构建块的天然基质的简易工程，以产生具有一系列有前途的特征的治疗性纳米复合水凝胶（BP/Gel）。BP纳米片可以增强交联网络，显著提高其矿化能力。BP/Gel纳米复合水凝胶具有优异的近红外光热性能和良好的生物相容性。在近红外辐射下，纳米复合水凝胶表现出有效的光热抗菌功能。更值得注意的是，BP纳米片工程化水凝胶基质能够在不存在骨诱导因子的情况下促进体外成骨，同时在Sprague-Dawley大鼠模型中显示出显著的新生颅骨组织形成。这些结果表明，BP纳米片可以赋予天然基质多种功能，包括增强网络，光热性能，增强矿化和骨再生，这为骨组织工程提供了一种简单而高效的治疗策略。
Natural polysaccharides and proteins have been widely explored for the preparation of hydrogel matrices due to their promising biocompatibility and biodegradability. However, it is challenging to achieve multiple functions of the hydrophilic matrix through convenient functionalization strategies. Herein we report the facile engineering of a natural matrix with black phosphorus (BP) nanosheets as building blocks to generate a therapeutic nanocomposite hydrogel (BP/Gel) with an array of promising features. BP nanosheets could reinforce the crosslinking networks and significantly promote their capabilities of mineralization. The BP/Gel nanocomposite hydrogel exhibits excellent near infrared (NIR) photothermal performance and good biocompatibility in vitro and in vivo. Upon NIR irradiation, the nanocomposite hydrogel demonstrates efficient photothermal antibacterial features. More remarkably, the BP nanosheet engineered hydrogel matrix is capable of promoting in vitro osteogenesis in the absence of osteoinductive factors, and in the meantime demonstrates significant newborn cranial bone tissue formation in a Sprague-Dawley rat model. These results demonstrate that BP nanosheets could endow the natural matrix with multiple functions including reinforced networks, photothermal performance, enhanced mineralization and bone regeneration, which provides a facile and highly efficient therapeutic strategy for bone tissue engineering.