Lack of age-related decreases in basal whole leg blood flow in resistance-trained men
Lack of age-related decreases in basal whole leg blood flow in resistance-trained men
复制标题
DOI：
10.1152/japplphysiol.00061.2005
复制
发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Tabata, I
中科院分区：
文献类型：
--
作者：
Miyachi, M;Tanaka, H;Tabata, I
在人类的代谢综合征和功能障碍的发病机制中已经涉及到基础腿部血流的减少。我们检验了这样一个假设，即在那些进行常规力量训练的人中，基础全腿血流量随年龄的减少要么不存在，要么减弱。对104名血压正常的男性进行了研究，年龄分别为20-34岁（青年）和35-65岁（中年），他们都是久坐或阻力训练者。中年组的平均血压和舒张压均高于青年组（P < 0.05-0.001），但久坐组和阻力训练组之间无显著性差异。在久坐组中，中年人的基础全腿血流（双功多普勒超声）和血管传导性低于年轻人（分别为30%和38%; P < 0.01）。在阻力训练组中没有这种年龄相关的差异。在年轻男性中，两个活动组之间的基础全腿血流量和血管传导性没有差异，但在中年男性中，阻力训练组的基础全腿血流量和血管传导性高于久坐组（分别为35%和36%; P < 0.01）。当血流量和血管传导性相对于腿部肌肉质量表示时，结果基本相同。我们的结论是，与年龄相关的减少基础全腿血流量是不存在的阻力训练的男子。这些结果表明，阻力训练可能会对老年人的腿部灌注产生有利影响，而与其对腿部肌肉质量的影响无关。
Reductions in basal leg blood flow have been implicated in the pathogenesis of metabolic syndrome and functional impairment in humans. We tested the hypothesis that reductions in basal whole leg blood flow with age are either absent or attenuated in those who perform regular strength training. A total of 104 normotensive men aged 20-34 yr (young) and 35-65 yr (middle aged), who were either sedentary or resistance trained, were studied. Mean and diastolic blood pressures were higher (P < 0.05-0.001) in the middle-aged compared with the young men, but there were no significant differences between the sedentary and resistance-trained groups. In the sedentary group, basal whole leg blood flow (duplex Doppler ultrasound) and vascular conductance were lower (similar to 30 and similar to 38%, respectively; P < 0.01) in the middle-aged compared with the young men. There were no such age-related differences in the resistance-trained group. In the young men, basal whole leg blood flow and vascular conductance were not different between the two activity groups, but, in the middle-aged men, they were higher (similar to 35 and similar to 36%, respectively; P < 0.01) in the resistance-trained men than in the sedentary men. When blood flow and vascular conductance were expressed relative to the leg muscle mass, the results were essentially the same. We concluded that the age-related reduction in basal whole leg blood flow is absent in resistance-trained men. These results suggest that resistance training may favorably influence leg perfusion in aging humans, independent of its impact on leg muscle mass.