EGFR mutations in non-small-cell lung cancer among smokers and non-smokers: A meta-analysis
EGFR mutations in non-small-cell lung cancer among smokers and non-smokers: A meta-analysis
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吸烟者和非吸烟者中非小细胞肺癌的 EGFR 突变：荟萃分析
DOI：
10.1002/em.20680
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Wu, Gang
中科院分区：
文献类型：
--
作者：
Ren, Jing-Hua;He, Wen-Shan;Wu, Gang
Mounting evidence has suggested somatic mutations in the EGFR gene are associated with better responsiveness to EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer (NSCLC). Some, but not all, studies have reported that the mutations were more frequently observed in patients without a smoking history. To comprehensively address this issue, we performed a meta-analysis to evaluate the association between cigarette-smoking history and mutation of the EGFR gene in NSCLC. Twenty-six studies, involving 3,688 patients with NSCLC were included in the analysis. The pooled analysis shows that the incidence of EGFR mutations in NSCLC differs according to cigarette-smoking history. The odds ratio (OR) for the EGFR mutation in non-smokers relative to smokers was 4.829 (95% confidence interval [CI]: 3.5986.482; P < 0.001). These data may assist clinicians in assessing the likelihood of EGFR mutations in patients with NSCLC when mutational analysis is not feasible. Environ. Mol. Mutagen. 2012. (C) 2011 Wiley Periodicals, Inc.
