AMIODARONE-INDUCED THROMBOCYTOPENIA
AMIODARONE-INDUCED THROMBOCYTOPENIA
复制标题
DOI：
10.1001/archinte.147.4.735
复制
发表时间：
1987-04-01
影响因子：
--
通讯作者：
AGMON, J
中科院分区：
文献类型：
--
作者：
WEINBERGER, I;ROTENBERG, Z;AGMON, J
盐酸胺碘酮诱导的血小板减少症似乎是胺碘酮治疗过程中的另一个副作用。本文描述了两例在胺碘酮治疗期间血小板减少的患者，其中胺碘酮诱导的血小板减少的诊断是由于在胺碘酮治疗期间血小板减少的发生和药物的再挑战。胺碘酮诱导的血小板减少症可能是由于迟发性超敏反应，如使用胺碘酮的淋巴细胞刺激试验结果强烈阳性所示。根据我们的研究结果，血小板计数应纳入患者开始胺碘酮治疗后的前两周的常规随访。
Amiodarone hydrochloride-induced thrombocytopenia seems to be an additional side effect in the course of amiodarone treatment. Two patients with thrombocytopenia during amiodarone treatment are described, in whom the diagnosis of amiodarone-induced thrombocytopenia was made by the fact that thrombocytopenia developed during amiodarone treatment and by rechallenge with the drug. Amiodarone-induced thrombocytopenia is probably due to delayed hypersensitivity reaction as indicated by the strongly positive lymphocyte stimulation test results using amiodarone. According to our results, platelet counts should be included in the routine follow-up to patients within the first two weeks after initiation of amiodarone treatment.