Intramitochondrial inclusions caused by depletion of creatine in rat skeletal muscles.
Intramitochondrial inclusions caused by depletion of creatine in rat skeletal muscles.
复制标题
大鼠骨骼肌肌酸消耗引起的线粒体内包涵体。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
C. S. Chen
中科院分区：
文献类型：
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作者：
Y. Ohira;M. Kanzaki;C. S. Chen
研究了β-胍基丙酸（β-GPA）喂养导致肌酸耗竭对大鼠线粒体形态学的影响。在β-GPA喂养9周后，在骨骼肌中观察到平行于线粒体长轴的线粒体内包涵体。一束包裹体由四个平行阵列组成，其中含有电子致密材料。两个外阵列是连续的结晶膜和两个内阵列的细颗粒链。线粒体与这样的夹杂物延长可能只在一定的方向，即使有人建议，层的嵴是拉直的二维。较长的线粒体与肌纤维平行。也有人建议，慢性刺激线粒体生物发生的消耗高能磷酸盐可能会导致这种夹杂物内线粒体。
Effect of creatine depletion by beta-guanidinopropionic acid (beta-GPA) feeding on mitochondrial morphology was studied in rats. Following beta-GPA feeding for 9 weeks, intramitochondrial inclusions running parallel to the long axis of mitochondrion were observed in skeletal muscles. A bundle of inclusions consisted of four parallel arrays containing electron-dense materials. Two outer arrays were continuous with cristal membranes and two inner arrays were chains of fine particles. Mitochondria with such inclusions were elongated probably in only a certain direction even though it was suggested that the layers of cristae were straightened two-dimensionally. Longer mitochondria ran parallel to the muscle fibers. It was also suggested that chronic stimulation of mitochondrial biogenesis by depletion of high energy phosphates may induce such inclusions within mitochondria.
诱导缺铁大鼠肌肉中线粒体基质酶的增加。
DOI：
10.1152/ajpcell.1987.253.5.c639
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
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作者：
Ohira,Y;Cartier,LJ;Chen,M;Holloszy,JO
通讯作者：
Holloszy,JO