SESQUITERPENE JUVENILE HORMONES - NOVEL UNCOUPLERS OF OXIDATIVE-PHOSPHORYLATION
SESQUITERPENE JUVENILE HORMONES - NOVEL UNCOUPLERS OF OXIDATIVE-PHOSPHORYLATION
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DOI：
10.1016/0006-291x(78)91028-8
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发表时间：
1978-01-01
影响因子：
3.1
通讯作者：
CHEFURKA, W
中科院分区：
文献类型：
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作者：
CHEFURKA, W
几种具有昆虫生长调节能力的天然无环倍半萜已被证明可以解开小鼠肝脏线粒体中的氧化磷酸化。这些药物刺激琥珀酸氧化，逆转寡霉素抑制的 3 态呼吸，激活 ATP 水解，诱导呼吸控制丧失并消除 ADP O 比率。内膜对钾、钠、铵、氯离子以及质子的渗透性也增强。由于这些试剂的结构排除了质子传递活性，因此讨论了这些保幼激素解偶联的可能机制。
Several natural acyclic sesquiterpenes with capacity for insect growth regulation have been shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. These agents stimulate succinate oxidation, reverse oligomycin-inhibited state 3 respiration, activate ATP-hydrolysis, induce loss of respiratory control and abolish ADP O ratio. Permeability of the inner membrane to potassium, sodium, ammonium and chloride ions as well as to protons is also enhanced. Since the structure of these agents precludes protonophoric activity, the possible mechanism of uncoupling by these juvenile hormones is discussed.