THE COLLAGEN SUPERFAMILY
THE COLLAGEN SUPERFAMILY
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DOI：
10.1159/000237090
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发表时间：
1995-08-01
影响因子：
2.8
通讯作者：
TIMPL, R
中科院分区：
文献类型：
--
作者：
BROWM, JC;TIMPL, R
胶原蛋白代表位于细胞外基质中的一大类模块化蛋白质。它们都共享一个可变长度（100-450 mn）的三螺旋段，但其球状结构域的大小和性质差异很大。迄今为止在脊椎动物中已知的各种胶原蛋白类型 I-XIX 被调整以适应不同的功能，包括原纤维、微原纤维和网络的形成。现在越来越多地通过遗传学方法来研究它们的生物学作用。
The collagens represent a large family of modular proteins which are located in the extracellular matrix. They all share a triple-helical segment of variable length (100-450 mn) but differ considerably in the size and nature of their globular domains. The various collagen types I-XIX known so far in vertebrates are adjusted to different functions including the formation of fibrils, microfibrils and networks. Their biological role is now increasingly studied by genetic approaches.