microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
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DOI：
10.1038/s41564-023-01575-9
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发表时间：
2024-02-01
影响因子：
28.3
通讯作者：
Dorrestein，Pieter C.
中科院分区：
文献类型：
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作者：
Zuffa，Simone;Schmid，Robin;Dorrestein，Pieter C.
microbeMASST 是一种分类学信息质谱 (MS) 搜索工具，可解决非目标代谢组学实验中有限的微生物代谢物注释问题。利用包含超过 60,000 种微生物单一培养物的精选数据库，用户可以搜索已知和未知的 MS/MS 谱图，并通过 MS/MS 碎片模式将它们与各自的微生物生产者联系起来。在没有先验知识的情况下鉴定微生物衍生的代谢物和相关生产者将极大地增强对微生物在生态和人类健康中的作用的理解。
microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms’ role in ecology and human health.