Factors affecting red blood cell storage age at the time of transfusion
Factors affecting red blood cell storage age at the time of transfusion
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DOI：
10.1111/trf.12171
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发表时间：
2013-12-01
期刊：
影响因子：
2.9
通讯作者：
Wendel, Silvano
中科院分区：
文献类型：
--
作者：
Dzik, Walter H.;Beckman, Neil;Wendel, Silvano
临床试验正在研究减少红细胞（rbc）最大储存间隔所带来的潜在益处。在不同的医院，决定红细胞年龄的关键因素各不相同。虽然红细胞最长储存期的逐步缩短预计会导致医院库存减少和血液供应减少，但其影响程度尚不清楚。研究设计与方法从5个国家的11家医院和3个血液中心收集当前医院血液清单的数据。在考虑到医院对红细胞的需求的基础上，开发了红细胞年龄的一般预测模型。结果问题红细胞的年龄对以下因素敏感：ABO血型、医院收货时的储存年龄、补库间隔、库存储备、平均需求和需求变化。结论基于医院需求的简单模型可作为检验医院库存中红细胞贮存年龄影响因素的基础。该模型表明，红细胞在向患者发放时的年龄取决于医院输血服务以外的因素。储存红细胞有效期的任何实质性变化都需要解决红细胞需求的广泛变化，同时试图平衡可获得性和血液浪费的考虑。
BackgroundClinical trials are investigating the potential benefit resulting from a reduced maximum storage interval for red blood cells (RBCs). The key drivers that determine RBC age at the time of issue vary among individual hospitals. Although progressive reduction in the maximum storage period of RBCs would be expected to result in smaller hospital inventories and reduced blood availability, the magnitude of the effect is unknown.Study Design and MethodsData on current hospital blood inventories were collected from 11 hospitals and three blood centers in five nations. A general predictive model for the age of RBCs at the time of issue was developed based on considerations of demand for RBCs in the hospital.ResultsAge of RBCs at issue is sensitive to the following factors: ABO group, storage age at the time of receipt by the hospital, the restock interval, inventory reserve, mean demand, and variation in demand.ConclusionsA simple model, based on hospital demand, may serve as the basis for examining factors affecting the storage age of RBCs in hospital inventories. The model suggests that the age of RBCs at the time of their issue to the patient depends on factors external to the hospital transfusion service. Any substantial change in the expiration date of stored RBCs will need to address the broad variation in demand for RBCs while attempting to balance considerations of availability and blood wastage.