Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients’ primary care records in situ using OpenSAFELY.
Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients’ primary care records in situ using OpenSAFELY.
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DOI：
10.3399/bjgp.2021.0376
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
(The OpenSAFELY Collaborative)
中科院分区：
文献类型：
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作者：
Curtis HJ;Inglesby P;Morton CE;MacKenna B;Green A;Hulme W;Walker AJ;Morley J;Mehrkar A;Bacon S;Hickman G;Bates C;Croker R;Evans D;Ward T;Cockburn J;Davy S;Bhaskaran K;Schultze A;Rentsch CT;Williamson EJ;Rowan A;Fisher L;McDonald HI;Tomlinson L;Mathur R;Drysdale H;Eggo RM;Wing K;Wong AY;Forbes H;Parry J;Hester F;Harper S;O'Hanlon S;Eavis A;Jarvis R;Avramov D;Griffiths P;Fowles A;Parkes N;Douglas IJ;Evans SJ;Smeeth L;Goldacre B;(The OpenSAFELY Collaborative)
2020年12月8日，英国国民保健署（NHS）首次接种COVID-19疫苗。描述在疫苗推广的前100天内，不同临床和人口群体的疫苗覆盖率的趋势和变化。在英国NHS的批准下，使用OpenSAFELY在英国的全科实践中，在电子健康记录软件供应商EMIS和TPP的基础设施内进行了5790万份患者记录的队列研究。描述了疫苗接种和免疫联合委员会（JCVI）优先队列各亚组的疫苗覆盖率。2020年12月8日至2021年3月17日期间，共有20 852 692名患者（36. 0%）接种了疫苗。在年龄≥80岁、不在护理之家的患者中（JCVI第2组），94.7%的患者接受了疫苗接种，但种族（白色96.2%，黑人68.3%）和贫困（最贫困96.6%，最贫困90.7%）存在显著差异。有既往病史的患者更有可能接种疫苗，但有两个例外：严重精神疾病（89.5%）和学习障碍（91.4%）。有275 205名疫苗接种者被确定为护理之家居民（JCVI第1组;覆盖率为91.2%）。截至3月17日，1 257 914名（6.0%）接受了第二剂。NHS迅速提供了大规模疫苗接种。在这项研究中，使用可公开审计的方法和安全的原位处理模型部署了一个数据监测框架，使用了5790万患者的关联但不精确的患者级NHS数据。可能需要开展有针对性的活动，以解决在某些关键群体中观察到的疫苗接种覆盖率较低的问题。
On 8 December 2020 NHS England administered the first COVID-19 vaccination. To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout. With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY. Vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts is described. A total of 20 852 692 patients (36.0%) received a vaccine between 8 December 2020 and 17 March 2021. Of patients aged ≥80 years not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2%, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5%) and learning disability (91.4%). There were 275 205 vaccine recipients who were identified as care home residents (JCVI group 1; 91.2% coverage). By 17 March, 1 257 914 (6.0%) recipients had a second dose. The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure in situ processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups.