Acute respiratory failure induced by tracheal instillation of xanthine oxidase, its prevention and therapy by exogenous surfactant instillation.
Acute respiratory failure induced by tracheal instillation of xanthine oxidase, its prevention and therapy by exogenous surfactant instillation.
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气管滴注黄嘌呤氧化酶所致急性呼吸衰竭及外源性表面活性剂滴注的预防和治疗
DOI：
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发表时间：
1987
影响因子：
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通讯作者：
W. Erdmann
中科院分区：
文献类型：
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作者：
B. Lachmann;O. Saugstad;J. Klein;W. Erdmann
氧自由基在多种疾病中起重要作用。产生超氧自由基的次黄嘌呤-黄嘌呤氧化酶系统对包括肺在内的多个器官产生损伤作用（综述：Saugstad 1985）。已经表明，与单独的次黄嘌呤或氧气相比，在呼吸100%氧气的大鼠中静脉内次黄嘌呤可引起肺损伤（Saugstad等人，1984年a）。此外，已经表明（约翰逊等人，1981），该系统急性诱导大鼠肺中毛细血管通透性增加。我们已经证明，黄嘌呤氧化酶（XO）应用于豚鼠气管诱导肺胸顺应性的显着变化，在几分钟的过程中，通过破坏支气管和肺泡表面活性剂系统的功能完整性，可能是通过形成氧自由基（FOR）。这种作用可以部分地被超氧化物歧化酶（SOD）阻止，超氧化物歧化酶是一种超氧化物自由基清除剂（Saugstad等人，1984年b）。本研究旨在探讨气管内滴注天然表面活性物质（NS）是否可能影响FOR引起的功能变化。
Free oxygen radicals play an important role in a variety of diseases. The hypoxanthine-xanthine oxidase system, which generates the superoxide radical, exerts a damaging effect on several organs, including the lung (Review: Saugstad 1985). It has been shown that intravenous hypoxanthine in rats breathing 100% oxygen can cause lung damage, in contrast to hypoxanthine or oxygen alone (Saugstad et al., 1984a). Further, it has been shown (Johnson et al., 1981) that this system acutely induces increased capillary permeability in the rat lung. We have demonstrated that xanthine oxidase (XO) applied to the trachea of guinea-pigs induces dramatic changes in lung-thorax compliance, in the course of a few minutes, by destroying the functional integrity of the bronchial and alveolar surfactant system, probably by formation of free oxygen radicals (FOR). This effect could be partly prevented by superoxide dismutase (SOD) which is a superoxide radical scavenger (Saugstad et al., 1984b). The purpose of this study was to investigate whether it is possible to influence the functional changes induced by FOR by tracheal instillation of natural surfactant (NS).