LUPUS PLEURITIS - CLINICAL-FEATURES AND PLEURAL FLUID CHARACTERISTICS WITH SPECIAL REFERENCE TO PLEURAL FLUID ANTI-NUCLEAR ANTIBODIES
LUPUS PLEURITIS - CLINICAL-FEATURES AND PLEURAL FLUID CHARACTERISTICS WITH SPECIAL REFERENCE TO PLEURAL FLUID ANTI-NUCLEAR ANTIBODIES
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DOI：
10.1378/chest.84.6.714
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发表时间：
1983-01-01
期刊：
影响因子：
9.6
通讯作者：
SAHN, SA
中科院分区：
文献类型：
--
作者：
GOOD, JT;KING, TE;SAHN, SA
对18例红斑狼疮(LE)和胸腔积液患者进行了评估。14例为狼疮性胸膜炎，4例为其他原因的胸腔积液。所有患者都有症状，目前的体征和症状并不能帮助区分狼疮性胸膜炎和其他原因的胸腔积液。LE细胞的存在证实了8例患者中7例狼疮性胸膜炎的诊断。在13例狼疮性胸膜炎患者中，11例胸水抗核抗体(ANA)滴度为0。13例狼疮性胸膜炎患者中，9例胸液/血清(PF/S)ANA比值为0。1.在4例LE伴其他原因胸腔积液患者中，胸液ANA滴度阴性2例，低滴度2例(1：40，1：80)，胸液ANA滴度与血清ANA滴度之比始终为<1；狼疮性胸膜炎的体征和症状是非特异性的；胸液中LE细胞的发现证实了诊断，胸液ANA滴度较高(.1：160)和PF/S的ANA比率为.1强烈支持这一诊断。
Patients (18) with lupus erythematosus (LE) and pleural effusions were evaluated. Fourteen patients had lupus pleuritis and 4 had pleural effusions of other etiologies. All patients were symptomatic, and the presenting signs and symptons did not help distinguish between lupus pleuritis and pleural effusions of other causes. The presence of LE cells confirmed the diagnosis of lupus pleuritis in 7 of 8 patients. In 11 of 13 patients with lupus pleuritis, the pleural fluid antinuclear antibody (ANA) titer was .gtoreq. 1:160, and in 9 of 13 patients with lupus pleuritis, the pleural fluid to serum (PF/S) ANA ratio was .gtoreq. 1. In the 4 patients with LE and a pleural effusion of another etiology, the pleural fluid ANA titer was negative in 2 and low titer in 2 (1:40, 1:80); the pleural fluid to serum ANA titer was always < 1. Of 67 patients with pleural effusions of other etiologies, the pleural fluid ANA was negative. Signs and symptoms of lupus pleuritis are nonspecific; findings of LE cells in pleural fluid confirms the diagnosis and a high pleural fluid ANA titer (.gtoreq. 1:160) and a PF/S ANA ratio of .gtoreq. 1 strongly supports the diagnosis.