Protein Aggregation as a Bacterial Strategy to Survive Antibiotic Treatment.
Protein Aggregation as a Bacterial Strategy to Survive Antibiotic Treatment.
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DOI：
10.3389/fmolb.2021.669664
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发表时间：
2021
影响因子：
5
通讯作者：
Michiels J
中科院分区：
文献类型：
--
作者：
Bollen C;Dewachter L;Michiels J
虽然蛋白质聚集主要与功能丧失和毒性有关，但也知道它可以增加细菌在压力条件下的存活率。事实上，蛋白质聚集不仅可以帮助细菌应对热休克或氧化应激等蛋白质毒性压力，而且越来越多的研究表明，它还可以通过诱导休眠来提高抗生素治疗期间的存活率。休眠细胞的一个众所周知的例子是持久性细胞，它们对抗生素的作用暂时不起作用。在没有抗生素的情况下，这些持久性细胞可以切换回易感状态并恢复生长，因此被认为是感染复发的重要原因。现在越来越多的证据表明，这种耐抗生素的持续状态与蛋白质聚集密切相关，甚至可能是由蛋白质聚集驱动的。此外，另一种休眠细菌表型，活菌但不可培养（VBNC）状态，也被证明与聚集有关。这些结果表明，在蛋白质渐进式聚集的诱导下，持久性细胞和VBNC细胞可能处于同一休眠程序的不同阶段。在这篇综述中，我们讨论了聚集与细菌休眠之间的关系，重点讨论了持久性细胞和VBNC细胞。了解蛋白质聚集和休眠之间的联系不仅能让我们深入了解细菌生存的基本原理，而且在我们未来与它们的战斗中可能被证明是非常有价值的。
While protein aggregation is predominantly associated with loss of function and toxicity, it is also known to increase survival of bacteria under stressful conditions. Indeed, protein aggregation not only helps bacteria to cope with proteotoxic stresses like heat shocks or oxidative stress, but a growing number of studies suggest that it also improves survival during antibiotic treatment by inducing dormancy. A well-known example of dormant cells are persisters, which are transiently refractory to the action of antibiotics. These persister cells can switch back to the susceptible state and resume growth in the absence of antibiotics, and are therefore considered an important cause of recurrence of infections. Mounting evidence now suggests that this antibiotic-tolerant persister state is tightly linked to—or perhaps even driven by—protein aggregation. Moreover, another dormant bacterial phenotype, the viable but non-culturable (VBNC) state, was also shown to be associated with aggregation. These results indicate that persisters and VBNC cells may constitute different stages of the same dormancy program induced by progressive protein aggregation. In this mini review, we discuss the relation between aggregation and bacterial dormancy, focusing on both persisters and VBNC cells. Understanding the link between protein aggregation and dormancy will not only provide insight into the fundamentals of bacterial survival, but could prove highly valuable in our future battle to fight them.
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发表时间：
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影响因子：
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