Pericytes in Bone Marrow
Pericytes in Bone Marrow
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DOI：
10.1007/978-3-030-11093-2_6
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Kunisaki, Yuya
中科院分区：
文献类型：
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作者：
Kunisaki, Yuya
骨髓环境由多种细胞类型组成，其中大多数被认为来自间充质干细胞。在小鼠骨髓中，具有CD45(-) Tie2(-) CD90(-) CD51(+) CD105（+）表型的基质细胞、nesting - gfp（+）、cxcl12丰富的网状（CAR）细胞、PDGFRa(+) Sca-1（+）或CD51(+) PDGFR α(+)和prx -1衍生的CD45- ter119 -PDGFRa(+) Sca-1（+）群体选择MSC活性。有证据表明，这些基质细胞群彼此之间有一些显著的重叠，并构成造血干细胞生态位的重要细胞成分。此外，这些间充质细胞群在它们的位置上有共同的特点，因为它们都在骨髓血管周围发现（可称为“周细胞”）。在本章中，通过回顾最近的文献，讨论了周细胞与生理性和病理性造血的关系。
Bone marrow environments are composed of multiple cell types, most of which are thought to be derived from mesenchymal stem cells. In mouse bone marrow, stromal cells with CD45(-) Tie2(-) CD90(-) CD51(+) CD105(+) phenotype, Nestin-GFP(+), CXCL12-abundant reticular ( CAR) cells, PDGFRa(+) Sca-1(+) or CD51(+) PDGFR alpha(+), and Prx-1-derived CD45-Ter119-PDGFRa(+) Sca-1(+) populations select for MSC activity. There is evidence that these stromal cell populations display some significant overlap with each other and comprise important cellular constituents of the hematopoietic stem cell niche. Moreover, these mesenchymal cell populations share characteristics in their location as they all are found around bone marrow vessels (can be called " pericytes"). In this chapter, with reviewing the recent literatures, how the pericytes relate to physiological and pathological hematopoiesis is argued.