Inhibition of experimental autoimmune uveitis by amino acid copolymers.
Inhibition of experimental autoimmune uveitis by amino acid copolymers.
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DOI：
10.1016/j.jneuroim.2009.08.002
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发表时间：
2009-10-30
影响因子：
3.3
通讯作者：
Gery I
中科院分区：
文献类型：
--
作者：
Yin H;Vistica BP;Chan CC;Strominger JL;Gery I
醋酸格拉替雷（GA）是一种合成的无规氨基酸共聚物，聚（Y，E，A，K）n，广泛用于治疗多发性硬化症。它通过与抗原竞争和诱导调节性T细胞来抑制小鼠实验性自身免疫性脑脊髓炎（EAE）。一种新型的共聚物，聚（F，Y，A，K）n，命名为FYAK，在其免疫调节活性在EAE中比GA更有效。在这里，比较了FYAK和GA对小鼠另一种疾病模型实验性自身免疫性视网膜色素层炎（EAU）的改善作用。当用致葡萄膜炎抗原进行共免疫试验时，FYAK在抑制EAU诱导以及与这种情况相关的免疫过程的能力方面上级于GA。此外，在EAU模型中，FYAK特异性调节性T细胞系比GA特异性系更具免疫抑制性。FYAK特异性品系的优越性伴随着Th2细胞因子的较高产生。因此，这些数据表明，FYAK，一种新的共聚物，是上级的GA在其能力，以抑制非中枢神经系统组织中的免疫病理过程。
Glatiramer acetate (GA), a synthetic random amino acid copolymer, poly(Y, E, A, K)n, is widely used for treatment of multiple sclerosis. It inhibits experimental autoimmune encephalomyelitis (EAE) in mice by competition with the antigen and by induction of regulatory T cells. A novel copolymer, poly (F, Y, A, K)n, designated FYAK, was more effective than GA in its immunomodulatory activity in EAE. Here, FYAK and GA were compared in the amelioration of another disease model in mice, experimental autoimmune uveoretinitis (EAU). When tested by co-immunization with a uveitogenic antigen, FYAK was superior to GA in its capacity to inhibit EAU induction, as well as immune processes related to this condition. Further, regulatory T cell lines specific to FYAK were more immunosuppressive than GA-specific lines in the EAU model. The superiority of FYAK-specific lines was accompanied by higher production of Th2 cytokines. These data thus demonstrate that FYAK, a novel copolymer, is superior to GA in its capacity to inhibit immunopathogenic processes in a non-central nervous system tissue.
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影响因子：
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作者：
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通讯作者：
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