Effect of cigarette smoking on levels of bioavailable testosterone in healthy men
Effect of cigarette smoking on levels of bioavailable testosterone in healthy men
复制标题
DOI：
10.1042/cs20010011
复制
发表时间：
2001-06-01
期刊：
影响因子：
6
通讯作者：
Jones, TH
中科院分区：
文献类型：
--
作者：
English, KM;Pugh, PJ;Jones, TH
吸烟对雄激素水平的影响是重要的，因为最近对低水平雄激素与心血管疾病发展之间的联系感兴趣。许多研究检查吸烟对总睾酮和游离睾酮水平的影响，报告了相互矛盾的结果，但没有准确评估吸烟对生物可利用睾酮水平的影响[与性激素结合球蛋白（SHBG）无关]。我们对25名健康男性吸烟者和25名健康从不吸烟者进行了病例对照研究，年龄和体重指数匹配。测定清晨总睾酮、游离睾酮和生物可利用睾酮、17 β-雌二醇、SHBG和可替宁的水平，并比较两组之间的差异。水平的总（18.5 +/- 4.6 nM vs 15.1 +/- 4.9 nM，P = 0.01）和游离睾酮（462 +/- 91 pM对402 +/- 93 pM，P = 0.03）吸烟者分别高于非吸烟者，SHBG也是如此（34.1 +/- 12.8 vs 28.1 +/- 9.0 nM，P = 0.06）。吸烟者和非吸烟者之间的生物可利用睾酮水平（3.78 +/- 1.59 vs 3.51 +/- 1.26 nM，P = 0.49）或17 β-雌二醇水平（44.5 +/- 11.4 vs 42.3 +/- 11.5 pM，P = 0.50）无显著差异。这些数据表明，吸烟对睾酮的生物活性部分没有显着影响，但可能会通过改变SHBG水平来影响总睾酮和游离睾酮的水平。
The effect of smoking on androgen levels is important given the recent interest in the link between low levels of androgens and the development of cardiovascular disease. Numerous studies examining the effects of cigarette smoking on the levels of total and free testosterone have reported conflicting findings, but there has been no accurate assessment of the effects of cigarette smoking on the levels of bioavailable testosterone [not bound to sex hormone-binding globulin (SHBG)I, We attempted to determine whether smoking affects the level of bioavailable testosterone. We undertook a case-control study of 25 healthy male smokers and 25 healthy never-smokers, matched by age and body mass index. Early morning levels of total, free and bioavailable testosterone, 17 beta -oestradiol, SHBG and cotinine were determined and compared between the two groups. Levels of total (18.5 +/- 4.6 nM versus 15.1 +/- 4.9 nM, P = 0.01) and free testosterone (462 +/- 91 pM versus 402 +/- 93 pM, P = 0.03) were found to be higher in smokers compared with non-smokers respectively, as was SHBG (34.1 +/- 12.8 versus 28.1 +/- 9.0 nM, P = 0.06). There were no significant differences in the levels of bioavailable testosterone (3.78 +/- 1.59 versus 3.51 +/- 1.26 nM, P = 0.49) or 17 beta -oestradiol (44.5 +/- 11.4 versus 42.3 +/- 11.5 pM, P = 0.50) between smokers and non-smokers respectively. These data suggest that cigarette smoking has no significant effect on the biologically active fraction of testosterone, but may influence the levels of total and free testosterone through changes in the levels of SHBG.