Association between pain and the frailty phenotype in older men: longitudinal results from the Concord Health and Ageing in Men Project (CHAMP)
Association between pain and the frailty phenotype in older men: longitudinal results from the Concord Health and Ageing in Men Project (CHAMP)
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DOI：
10.1093/ageing/afy012
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发表时间：
2018-05-01
期刊：
影响因子：
6.7
通讯作者：
Blyth, Fiona M.
中科院分区：
文献类型：
--
作者：
Megale, Rodrigo Z.;Ferreira, Manuela L.;Blyth, Fiona M.
目的：使用纵向数据确定疼痛是否会增加发展为脆弱表型的风险，以及虚弱是否会增加发展为慢性或介入性疼痛的风险。设计/背景：来自协和健康与老龄化男性项目(CHAMP)的纵向数据，该项目是一项基于人群的前瞻性队列研究。参与者：共有1,705名年龄在70岁或以上的男性，居住在澳大利亚新南威尔士州的城市地区。测量：收集了慢性疼痛(至少3个月内每天疼痛)、侵袭性疼痛(导致中到重度活动干扰的疼痛)和心血管健康研究(CHS)脆弱表型标准的数据。2005年1月至2013年10月。研究还收集了年龄、生活安排、教育程度、吸烟状况、饮酒、体重指数、合并症、认知功能、抑郁症状和脊柱或髋部骨折病史等数据，并将其作为协变量纳入分析。结果：共有1,705名参与者进入基线，其中1,332人在2年随访时提供数据，940人在5年随访时提供数据。报告慢性疼痛的非虚弱(强壮和虚弱前)男性在随访时发生虚弱的可能性是没有疼痛的男性的1.6倍(95%可信区间：1.02-2.51，P=0.039)。侵袭性疼痛不会显著增加未来虚弱的风险。同样，在调整后的分析中，虚弱状态与未来的慢性或侵入性疼痛无关。结论：慢性疼痛的存在增加了社区老年男性发展为虚弱表型的风险。
Objectives: to determine whether pain increases the risk of developing the frailty phenotype and whether frailty increases the risk of developing chronic or intrusive pain, using longitudinal data.Design/Setting: longitudinal data from the Concord Health and Ageing in Men Project (CHAMP), a prospective population based cohort study.Participants: a total of 1,705 men aged 70 years or older, living in an urban area of New South Wales, Australia.Measurements: data on the presence of chronic pain (daily pain for at least 3 months), intrusive pain (pain causing moderate to severe interference with activities) and the criteria for the Cardiovascular Health Study (CHS) frailty phenotype were collected in three waves, from January 2005 to October 2013. Data on age, living arrangements, education, smoking status, alcohol consumption, body mass index, comorbidities, cognitive function, depressive symptoms and history of vertebral or hip fracture were also collected and included as covariates in the analyses.Results: a total of 1,705 participants were included at baseline, of whom 1,332 provided data at the 2-year follow-up and 940 at the 5-year follow-up. Non-frail (robust and pre-frail) men who reported chronic pain were 1.60 (95% confidence interval (CI): 1.02-2.51, P = 0.039) times more likely to develop frailty at follow-up, compared to those with no pain. Intrusive pain did not significantly increase the risk of future frailty. Likewise, the frailty status was not associated with future chronic or intrusive pain in the adjusted analysis.Conclusions: the presence of chronic pain increases the risk of developing the frailty phenotype in community-dwelling older men.