Orbitofrontal ensemble activity monitors licking and distinguishes among natural rewards
Orbitofrontal ensemble activity monitors licking and distinguishes among natural rewards
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DOI：
10.1152/jn.00467.2005
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Simon, SA
中科院分区：
文献类型：
--
作者：
Gutierrez, R;Carmena, JM;Simon, SA
有节奏的舔成簇的分类已被证明是有用的表征大脑机制，调节摄入的自然奖励（蔗糖和水）。一个对奖励刺激有反应的皮质区域是眶额皮质（OFC）。然而，目前还不知道OFC神经元如何响应，而啮齿动物自由舔的自然奖励，以及这些反应是否与舔集群的结构。我们解决了这些问题，表明OFC的暂时失活的持续时间减少，增加集群的数量和OFC神经元的活动在精确的时间之前，期间和之后的集群终止改变。此外，对眶额皮层神经元集合活动的分析表明，它们可以区分集群的开始和终止，预测行为动物何时开始开始集群，并区分和预测自然奖励。这些结果提供了一个新的作用，OFC在影响舔集群和预期特定的奖励。
The classification of rhythmic licking into clusters has proved to be useful for characterizing brain mechanisms that modulate the ingestion of natural rewards (sucrose and water). One cortical area that is responsive to rewarding stimuli is the orbitofrontal cortex (OFC). However, it is not presently known how OFC neurons respond while rodents freely lick for natural rewards and whether these responses are related to the structure of licking clusters. We addressed these issues by showing that temporary inactivation of the OFC decreases the duration and increases the number of clusters and that the activity of OFC neurons changed at precise times before, during, and after the cluster terminates. Furthermore, analysis of the activity of OFC neuronal ensembles showed that they could discriminate cluster onset from termination, predict when a behaving animal will begin a cluster, and distinguish and anticipate between natural rewards. These results provide a new role for the OFC in influencing licking clusters and anticipating specific rewards.