Pseudoexfoliative fibrillopathy in the conjunctiva. A relation to elastic fibers and elastosis.
Pseudoexfoliative fibrillopathy in the conjunctiva. A relation to elastic fibers and elastosis.
复制标题
结膜假性剥脱性纤维病。
DOI：
10.1016/s0161-6420(87)33268-3
复制
发表时间：
1987
期刊：
影响因子：
13.7
通讯作者：
Dark,AJ
中科院分区：
文献类型：
--
作者：
Streeten,BW;Bookman,L;Ritch,R;Prince,AM;Dark,AJ
对13例PSX病患者的眼结膜进行超微结构研究，发现PSX物质与弹性系统的成分密切相关。假性脱落聚集体在血管壁内罕见，但在基质成纤维细胞的质膜附近常见。没有发现淀粉样蛋白，一个显著的特征是PSX纤维与许多标本中可见的弹性组织变性相关。典型的PSX纤维存在于oxytalan的团块中和小的弹性纤维周围。在5例更先进的弹性组织变性，PSX纤维的聚集体较大，其通常的松散的纤维颗粒基质被广泛取代的致密的弹性组织变性。PSX的形态从典型的到较厚的、碎片化的，有时是非诊断性的纤维。PSX和弹性组织变性材料的这种混合表明PSX纤维病本身是一种弹性组织变性，可能是由与弹性微纤维相关的组分的异常聚集引起的。
Pseudoexfoliative (PSX) material in the conjunctiva was found to have a close association with elements of the elastic system in 13 eyes of patients with PSX disease studied ultrastructurally. Pseudoexfoliation aggregates were rare within vascular walls but frequent in proximity to the plasmalemma of stromal fibroblasts. No amyloid was found. A striking feature was the association of PSX fibers with the elastosis seen in many of the specimens. Typical PSX fibers were present in clumps of oxytalan and around small elastic fibers. In five cases with more advanced elastosis, the aggregates of PSX fibers were larger and their usual loose fibrogranular matrix was extensively replaced by a dense elastotic one. Morphology of PSX here varied from typical to thicker, fragmented, and sometimes nondiagnostic fibers. This intermingling of PSX and elastotic materials suggested that PSX fibrillopathy is itself a type of elastosis, possibly resulting from abnormal aggregation of components related to elastic microfibrils.