sst5 somatostatin receptor mRNA induction by mitogenic activation of human T-lymphocytes
sst5 somatostatin receptor mRNA induction by mitogenic activation of human T-lymphocytes
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DOI：
10.1016/s0196-9781(99)00036-4
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发表时间：
1999-01-01
期刊：
影响因子：
3
通讯作者：
Krantic, S
中科院分区：
文献类型：
--
作者：
El Ghamrawy, C;Rabourdin-Combe, C;Krantic, S
SRIF对免疫细胞（包括T淋巴细胞）具有神经免疫调节作用。通过RT-PCR分析静息和丝裂原活化的人T淋巴细胞中SRIF受体的表达，研究了参与这些作用的分子机制。我们的研究结果指出，有丝分裂原相关的诱导sst 5受体亚型。相反，SST 3受体在两种活性状态下均呈组成型表达。SRIF 14在活化的T淋巴细胞中的生物学作用的评估表明，在纳摩尔浓度范围内，该肽适度抑制有丝分裂原诱导的IL-2分泌。然而，T淋巴细胞增殖在SRIF 14的存在下不受抑制，而是甚至略微增加。总之，这些数据表明SRIF神经免疫调节作用的复杂机制。(C)1989年爱思唯尔科学公司All rights reserved.
SRIF has neuro-immunomodulatory actions on immune cells, including T-lymphocytes. Molecular mechanisms involved in these actions were studied by RT-PCR analysis of SRIF receptor expression in resting and mitogen-activated human T-lymphocytes. Our results point to the mitogen-associated induction of sst5 receptor subtype. Conversely, sst3 receptor appears constitutively expressed in both activity states. Assessment of biologic actions of SRIF14 in activated T-lymphocytes indicates that, in nanomolar concentration range, this peptide moderately inhibits mitogen-induced IL-2 secretion. Nevertheless, T-lymphocyte proliferation is not inhibited in the presence of SRIF14 but is even slightly increased. Altogether these data suggest a complex mechanism of SRIF neuro-immunomodulatory actions. (C) 1989 Elsevier Science Inc. All rights reserved.