Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime
Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime
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DOI：
10.1007/s10439-016-1781-5
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发表时间：
2017-01
影响因子：
3.8
通讯作者：
Y. Inoue;T. Yokota;T. Sekitani;Akiko Kaneko;Taeseong Woo;Shingo Kobayashi;Tomokazu Shibuya;Masaru Tanaka;H. Kosukegawa;I. Saito;T. Isoyama;Y. Abe;T. Yambe;T. Someya;M. Sekino
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文献类型：
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作者：
Y. Inoue;T. Yokota;T. Sekitani;Akiko Kaneko;Taeseong Woo;Shingo Kobayashi;Tomokazu Shibuya;Masaru Tanaka;H. Kosukegawa;I. Saito;T. Isoyama;Y. Abe;T. Yambe;T. Someya;M. Sekino
最近有报道称，混杂组织-织物材料具有良好的性能-高生物相容性和高机械强度。在这项研究中，我们证明了混合材料作为血液蛋白长期过滤器的能力。将聚酯织物植入大鼠体内以制造混杂组织-织物材料片材。混合材料包括生长在织物上的生物组织。植入后约100天，从大鼠体内提取材料。将组织脱细胞以防止免疫排斥。通过将血液滴到混合材料表面上进行抗血栓形成试验。混合材料显示出比聚砜和纤维素更少的血液凝固。用该杂化材料过滤血浆，评价其蛋白质去除率和体外使用寿命。混合材料显示出与常规过滤器相当的蛋白质去除性能。此外，杂化材料可以作为蛋白质过滤器工作1个月，这是聚砜寿命的6倍。
There are recent reports of hybrid tissue–fabric materials with good performance—high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue–fabric material sheets. The hybrid materials comprised biological tissue grown on the fabric. The materials were extracted from the rat’s body, approximately 100 days post-implantation. The tissues were decellularized to prevent immunological rejection. An antithrombogenicity test was performed by dropping blood onto the hybrid material surface. The hybrid material showed lesser blood coagulation than polysulfone and cellulose. Blood plasma was filtered using the hybrid material to evaluate the protein removal percentage and the lifetime of the hybrid materialin vitro. The hybrid material showed a comparable performance to conventional filters for protein removal. Moreover, the hybrid material could work as a protein filter for 1 month, which is six times the lifetime of polysulfone.