A very low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins.
A very low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins.
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DOI：
10.1097/00019616-199911000-00014
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发表时间：
1999-03
期刊：
影响因子：
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通讯作者：
D. Dreon;H. Fernstrom;Williams Ft;Ronald M. Krauss
中科院分区：
文献类型：
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作者：
D. Dreon;H. Fernstrom;Williams Ft;Ronald M. Krauss
背景我们以前发现，大LDL颗粒占优势的男性（表型A）食用高脂饮食（40-46%脂肪）比以小LDL占优势为特征的高危脂蛋白谱（表型B）男性显示出较少的低脂饮食（20-24%脂肪）的脂蛋白益处。此外，有三分之一的A型男性在食用高脂肪饮食后转变为B型。目的：我们研究了在高脂和低脂饮食中，进一步减少饮食脂肪对LDL亚类表型A持续存在的男性的影响。设计38名男性，在4-6周的高脂和低脂饮食后表现出A型，在10天内食用10%脂肪饮食（2.7%饱和脂肪），用碳水化合物代替脂肪，胆固醇含量或多不饱和脂肪酸与饱和脂肪酸的比例没有变化。结果在26名男性中，表型A持续存在（稳定A组），而12名转化为表型B（变化组）。两组的LDL胆固醇与先前20-24%脂肪饮食的值没有差异，而在变化组中，三酰甘油和载脂蛋白B浓度较高; HDL、大LDL-I、小LDL-III和LDL-IV以及HDL 3的质量较大; HDL胆固醇、载脂蛋白A-I浓度较低;大LDL-I和HDL 2的质量较低。结论：对于具有大LDL颗粒的男性，将膳食脂肪从20-24%减少到10%没有明显的脂蛋白益处：LDL-胆固醇浓度没有降低，并且在一个受试者子集中，随着三酰甘油增加和HDL-胆固醇浓度降低，沿着向小LDL转变。
BACKGROUND We found previously that men with a predominance of large LDL particles (phenotype A) consuming high-fat diets (40-46% fat) show less lipoprotein benefits of low-fat diets (20-24% fat) than do men with a high-risk lipoprotein profile characterized by a predominance of small LDL (phenotype B). Furthermore, one-third of men with phenotype A consuming a high-fat diet converted to phenotype B with a low-fat diet. OBJECTIVE We investigated effects of further reduction in dietary fat in men with persistence of LDL subclass phenotype A during both high- and low-fat diets. DESIGN Thirty-eight men who had shown phenotype A after 4-6 wk of both high- and low-fat diets consumed for 10 d a 10%-fat diet (2.7% saturates) with replacement of fat with carbohydrate and no change in cholesterol content or ratio of polyunsaturates to saturates. RESULTS In 26 men, phenotype A persisted (stable A group) whereas 12 converted to phenotype B (change group). LDL cholesterol did not differ from previous values for 20-24%-fat diets in either group, whereas in the change group there were higher concentrations of triacylglycerol and apolipoprotein B; greater mass of HDL, large LDL-I, small LDL-III and LDL-IV, and HDL3; lower concentrations of HDL cholesterol, apolipoprotein A-I; and lower mass of large LDL-I and HDL2. CONCLUSIONS There is no apparent lipoprotein benefit of reduction in dietary fat from 20-24% to 10% in men with large LDL particles: LDL-cholesterol concentration was not reduced, and in a subset of subjects there was a shift to small LDL along with increased triacylglycerol and reduced HDL-cholesterol concentrations.