Enantioselective total synthesis of convolutamydines B and E
Enantioselective total synthesis of convolutamydines B and E
复制标题
DOI：
10.1021/ol052871p
复制
发表时间：
2006-02-16
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Nakamura, T;Shirokawa, S;Kobayashi, S
利用乙烯基Mukaiyama醛醇缩合反应首次实现了旋绕胺B和E的对映选择性全合成。该合成具有高度非对映选择性的乙烯基Mukaiyama羟醛缩合反应，以靛红代替醛来构建旋绕胺的手性中心。此外，通过圆二色性光谱确定天然旋花碱B的绝对构型为R。
The first enantioselective total synthesis of convolutamydines B and E has been achieved using our vinylogous Mukaiyama aldol reaction. The synthesis features highly diastereoselective vinylogous Mukaiyama aldol reaction with isatin instead of aldehydes to construct a chiral center of convolutamydines. Additionally, the absolute configuration of natural convolutamydine B has been determined as R by its CD spectrum.