MITOCHONDRIAL-FUNCTION IN MYOCARDIAL STUNNING
MITOCHONDRIAL-FUNCTION IN MYOCARDIAL STUNNING
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DOI：
10.1016/0022-2828(91)90034-j
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发表时间：
1991-01-01
影响因子：
5
通讯作者：
VANBELLE, H
中科院分区：
文献类型：
--
作者：
FLAMENG, W;ANDRES, J;VANBELLE, H
研究了正常、缺血和缺血后兔心线粒体呼吸参数。线粒体功能与组织高能磷酸盐（HEP）含量和心功能有关。结果发现，在10和20分钟的全常温缺血后，Langendorff再灌注20分钟，心肌线粒体功能和HEP含量没有显着降低。与缺血前相比，心肌磷酸肌酸甚至显示出显著的过冲。当这些心脏被允许执行工作时，心功能恢复不完全，而线粒体功能和HEP含量保持在正常范围内。长时间缺血（30分钟）导致缺血期间和缺血后心肌线粒体功能和ATP含量的显着抑制。这些结果表明，轻度缺血性损伤（心肌顿抑）后受损的心脏功能可能与接近正常的线粒体功能和HEP含量有关。
Mitochondrial respiration parameters were studied in mitochondria isolated from normal, ischemic and post-ischemic rabbit hearts. Mitochondrial function was related to tissue content of high energy phosphates (HEP) and cardiac function in the isolated working rabbit heart preparation. It was found that after 10 and 20 mins of global normothermic ischemia followed by 20 mins of Langendorff reperfusion, mitochondrial function and HEP content of the myocardium were not significantly diminished. Myocardial creatine phosphate even showed a significant overshoot as compared to the pre-ischemic condition. When these hearts were allowed to perform work, recovery of cardiac function was incomplete while mitochondrial function and HEP content remained in the normal range. Prolonged ischemia (30 mins) resulted in a significant depression of mitochondrial function and myocardial ATP content during and after ischemia. Recovery of contractile function was severely depressed.These results show that impaired cardiac function after a mild ischemic insult (myocardial stunning) can be associated with near normal mitochondrial function and HEP contents.