A Double Dissociation Between Striate and Extrastriate Visual Cortex for Pattern Motion Perception Revealed Using rTMS
A Double Dissociation Between Striate and Extrastriate Visual Cortex for Pattern Motion Perception Revealed Using rTMS
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DOI：
10.1002/hbm.20736
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发表时间：
2009-10-01
影响因子：
4.8
通讯作者：
Hess, Robert F.
中科院分区：
文献类型：
--
作者：
Thompson, Benjamin;Aaen-Stockdale, Craig;Hess, Robert F.
通常使用格子刺激来研究运动信号整合和分离的神经机制。这些刺激由两个不同方向的空间重合动态光栅组成，它们要么被感知为沿两个独特的方向移动，要么被视觉系统集成以引发棋盘沿单个方向移动的感知。与各个组件光栅的运动相关的计算被认为发生在纹状皮层 (VI) 中，而运动整合被认为涉及背流纹外视觉区域中的神经元，特别是 V5/MT。通过将采用格子刺激与 1 Hz 离线重复经颅磁刺激 (rTMS) 的心理物理学任务相结合，我们证明了纹状和纹外视觉皮层在运动整合方面的双重分离。纹状皮层上的 rTMS 增加了连贯运动感知，而纹状外皮层上的 rTMS 则具有相反的效果。这些效应在刺激给药后立即显现出来，并在 15 分钟内逐渐恢复到基线。这种双重分离与之前的患者数据和最近的假设一致，即连贯和透明的运动感知同时受到视觉系统的支持，并争夺感知主导地位。 Hum Brain Mapp 30:31153126, 2009。(C) 2009 Wiley-Liss, Inc.
The neural mechanisms underlying the integration and segregation of motion signals are often studied using plaid stimuli. These stimuli consist of two spatially coincident dynamic gratings of differing orientations, which are either perceived to move in two unique directions or are integrated by the visual system to elicit the percept of a checkerboard moving in a single direction. Computations pertaining to the motion of the individual component gratings are thought to take place in striate cortex (VI) whereas motion integration is thought to involve neurons in dorsal stream extrastriate visual areas, particularly V5/MT. By combining a psychophysical task that employed plaid stimuli with 1 Hz offline repetitive transcranial magnetic stimulation (rTMS), we demonstrated a double dissociation between striate and extrastriate visual cortex in terms of their contributions to Motion integration. rTMS over striate cortex increased coherent motion percepts whereas rTMS over extrastriate cortex had the opposite effect. These effects were robust directly after the Stimulation administration and gradually returned to baseline within 15 minutes. This double dissociation is consistent with previous patient data and the recent hypothesis that both coherent and transparent motion percepts are Supported by the Visual system simultaneously and compete for perceptual dominance. Hum Brain Mapp 30:31153126, 2009. (C) 2009 Wiley-Liss, Inc.