The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex.
The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex.
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神经可塑性在抑郁症中的作用：从海马到前额皮质
DOI：
10.1155/2017/6871089
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发表时间：
2017
影响因子：
3.1
通讯作者：
Cui R
中科院分区：
文献类型：
--
作者：
Liu W;Ge T;Leng Y;Pan Z;Fan J;Yang W;Cui R
神经可塑性，神经元适应的基本机制，在抑郁症中被破坏。应激等负性刺激引起的神经可塑性改变在抑郁症的发生发展中起着重要作用。还发现抗抑郁治疗通过对神经可塑性的调节作用发挥其抗抑郁作用。然而，抑郁症神经可塑性的具体机制仍不清楚。因此，在这篇综述中，我们总结了最近的文献，阐述了神经可塑性在抑郁症中可能的机制作用。总之，这些发现可能为神经可塑性研究的未来进展铺平道路。
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.