Fatal Epstein-Barr virus infection in a child with acute lymphoblastic leukemia in remission.
Fatal Epstein-Barr virus infection in a child with acute lymphoblastic leukemia in remission.
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发表时间：
1981-11
期刊：
影响因子：
11.2
通讯作者：
A. Look;R. Naegele;T. Callihan;H. Herrod;W. Henle
中科院分区：
文献类型：
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作者：
A. Look;R. Naegele;T. Callihan;H. Herrod;W. Henle
一名9岁的白人男孩在接受急性淋巴细胞白血病化疗期间感染了致命的原发性eb病毒（EBV）。在疾病增殖阶段的组织病理学结果与病毒诱导的噬血细胞综合征相一致。感染自然地转化为骨髓和淋巴结的完全发育不全。血清学研究表明，患者在感染前没有EBV抗体，但在急性期，他显示出EBV特异性抗原的抗体谱和滴度，这是当前原发性EBV感染的特征。发病5周后的淋巴结活检显示约50%的细胞中有Epstein-Barr核抗原。男孩的病情迅速恶化，播散性念珠菌病导致心肺衰竭和死亡。尸检时获得的淋巴结不再含有Epstein-Barr核抗原阳性细胞。
A 9-year-old white boy developed a fatal primary Epstein-Barr virus (EBV) infection while receiving chemotherapy for acute lymphoblastic leukemia in remission. Histopathological findings at the height of the proliferative phase of the illness were compatible with a virally induced hemophagocytic syndrome. The infection spontaneously converted to complete aplasia of the bone marrow and lymph nodes. Serological studies disclosed that the patient had no antibodies to EBV prior to the infection, but during the acute phase he showed a spectrum and titers of antibodies to EBV-specific antigens characteristic of a current primary EBV infection. A lymph node biopsy obtained 5 weeks after onset revealed Epstein-Barr nuclear antigen in approximately 50% of the cells. The boy's condition deteriorated rapidly, with disseminated candidiasis resulting in cardiorespiratory failure and death. Lymph nodes obtained at autopsy no longer contained Epstein-Barr nuclear antigen-positive cells.