Risk factors of breast cancer in burma
Risk factors of breast cancer in burma
复制标题
缅甸乳腺癌的危险因素
DOI：
10.1002/ijc.2910210406
复制
发表时间：
1978
影响因子：
6.4
通讯作者：
Thein
中科院分区：
文献类型：
--
作者：
Thein;Thein
在仰光进行了一项基于医院的乳腺癌病例对照研究。年龄标准化发病率（25.1/100，000妇女年）和年龄发病率曲线的形状表明，与世界其他国家的妇女相比，仰光妇女的乳腺癌风险处于中等水平。该分析基于193例病例和400例对照。研究发现，乳腺癌风险与受教育程度直接相关。初潮早和绝经晚的风险增加。最引人注目的发现是风险和生育率之间的强烈反比关系;有六个或六个以上孩子的妇女患乳腺癌的风险只有四个孩子以下的已婚妇女的三分之一。这种关联不受第一个孩子出生时年龄的病例对照差异的混淆。乳腺癌风险与初次生育年龄的关联并不显著;只有30岁以后初次生育的妇女风险增加。乳腺癌风险与哺乳无关。总体而言，缅甸乳腺癌的流行病学与大多数其他国家相似。然而，风险与产次和首次分娩年龄之间的不寻常关系的可能性值得进一步探讨。
A hospital‐based case‐control study of breast cancer was undertaken in Rangoon. The age‐standardized incidence rate, 25.1 per 100,000 woman‐years and the shape of the age‐incidence curve show that Rangoon women have an intermediate level of breast cancer risk compared to women of other countries in the world. The analysis is based on 193 cases and 400 controls. Breast cancer risk was found to be directly related to educational attainment. There was an increased risk associated with early menarche and late menopause. The most striking finding was the strong inverse relationship between risk and parity; women who had six or more children have only one‐third the breast cancer risk of married women who had less than four children. This association is not confounded by case‐control differences in age at birth of first child. The association of breast cancer risk with age at first birth was not striking; only women with a first birth after age 30 were at increased risk. Breast cancer risk was unrelated to lactation. Overall, the epidemiology of breast cancer in Burma is similar to that in most other countries. However, the possibility of an unusual relationship of risk to parity and age at first parturition warrants further exploration.