Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population
Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population
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DOI：
10.1111/j.1469-0691.2009.03081.x
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发表时间：
2010-08-01
影响因子：
14.2
通讯作者：
Moriyama, M.
中科院分区：
文献类型：
--
作者：
Nguyen, L. T.;Uchida, T.;Moriyama, M.
幽门螺杆菌dupA基因可能是十二指肠溃疡的危险因素，但对胃癌具有保护作用。本研究旨在重新研究dupA在H.幽门螺杆菌感染的日本患者我们发现dupA状态与任何胃十二指肠疾病、慢性胃炎的组织学评分或胃细胞系产生白细胞介素-8的程度无关。这些结果表明dupA可能不是H. pylori在日本人中的作用
P>The dupA gene of Helicobacter pylori was suggested to be a risk factor for duodenal ulcer but protective against gastric cancer. The present study aimed to re-examine the role of dupA in H. pylori-infected Japanese patients. We found that dupA status was not associated with any gastroduodenal disease, histological score of chronic gastritis or with the extent of interleukin-8 production from gastric cell lines. These results indicate that dupA is unlikely to be a virulence factor of H. pylori in the Japanese population.