Potential Toxicities of High Doses of Naltrexone in Patients with Appetitive Disorders
Potential Toxicities of High Doses of Naltrexone in Patients with Appetitive Disorders
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高剂量纳曲酮对食欲障碍患者的潜在毒性
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
T. Kosten
中科院分区：
文献类型：
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作者：
C. Morgan;T. Kosten
纳洛酮是一种长效阿片拮抗剂，已被证明是有效的作为一个药理学辅助治疗脱毒阿片成瘾者。在1984年美国食品药品监督管理局批准该适应症之前，在8年的时间里，在2，000多名静脉注射阿片类药物滥用者中对纳洛酮进行了广泛的测试。根据这些试验，药物被认为是医学上安全的（Pfohl，艾伦，阿特金森，克诺普曼，马尔科姆，米切尔和莫利，1986）。因此，标题中的短语“潜在毒性”在描述这种药物时似乎过于令人担忧。不仅有大量的患者，有很好的理由有肝脏问题，在相对较长的时间间隔内安全地用纳洛酮治疗;但在正常人中，纳洛酮通常没有问题的副作用。
Naltrexone is a long acting opiate antagonist that has been shown to be efficacious as a pharmacologic adjunct in the treatment of detoxified opiate addicts. Prior to its approval for this indication in 1984 by the Food and Drug Administration, U.S.A., naltrexone was extensively tested over an 8-yr period in more than 2,000 intravenous abusers of opioids. Based on these trials, the medication was considered medically safe (Pfohl, Allen, Atkinson, Knopman, Malcolm, Mitchell & Morley, 1986). Thus, the phrase in the title, “potential toxicity,” may seem overly alarming in describing this medication. Not only have a large number of patients, with a good reason to have liver-problems, been safely treated with naltrexone over relatively prolonged intervals; but in normals, naltrexone is generally devoid of problematic side-effects.