In vivo transillumination biomicroscopy and photography of meibomian gland dysfunction. A clinical study.
In vivo transillumination biomicroscopy and photography of meibomian gland dysfunction. A clinical study.
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DOI：
10.1016/s0161-6420(85)33848-4
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发表时间：
1985-10
期刊：
影响因子：
13.7
通讯作者：
J. Robin;J. Jester;J. Nobe;Nicholas E. Nicolaides;Ronald E. Smith
中科院分区：
文献类型：
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作者：
J. Robin;J. Jester;J. Nobe;Nicholas E. Nicolaides;Ronald E. Smith
对18例临床上明显的睑板腺功能障碍（MGD）和皮肤病性酒渣鼻患者，22例无皮肤病性酒渣鼻的MGD患者和15例作为对照的未受影响的个体进行了睑板腺透照生物显微镜和红外摄影。所有具有MGD临床体征的患者均通过透照生物显微镜证实其睑板腺形态异常。没有皮肤病酒渣鼻的患者有不同程度的腺体变形。此外，红外线摄影记录了正常葡萄状黑点簇的损失，代表腺体，这表明腺泡的损失。皮肤病酒渣鼻患者有更严重的改变，包括显着的扭曲和正常腺体解剖的损失。在临床上未受影响的个体中无此类异常。这些数据表明，透照生物显微镜和红外摄影有能力识别MGD患者睑板腺的形态学改变谱。作者认为，这些技术可用于根据是否存在可识别的睑板腺异常对临床MGD进行分类。
Meibomian gland transillumination biomicroscopy and infrared photography were performed on 18 patients with clinically evident meibomian gland dysfunction (MGD) and dermatologic rosacea, 22 patients having MGD without evidence of dermatologic rosacea, and 15 unaffected individuals who served as controls. All patients having clinical signs of MGD demonstrated morphologic abnormalities of their meibomian glands by transilluminated biomicroscopy. Patients without dermatologic rosacea were noted to have varying degrees of gland distortion. Moreover, infrared photography documented a loss of the normal grape-like clusters of dark spots that represent the gland, suggesting a loss of glandular acini. Patients with dermatologic rosacea had more severe alterations, including marked distortion and loss of normal gland anatomy. There were no such abnormalities in clinically unaffected individuals. These data demonstrate that transilluminated biomicroscopy and infrared photography have the ability to identify a spectrum of morphologic alterations of the meibomian glands in MGD patients. The authors suggest that these techniques could be used to classify clinical MGD based upon the presence or absence of identifiable meibomian gland abnormalities.