Dendrobii Officinalis,N a traditional Chinese edible and officinal plant, accelerates liver recovery by regulating the gut-liver axis in NAFLD mice
Dendrobii Officinalis,N a traditional Chinese edible and officinal plant, accelerates liver recovery by regulating the gut-liver axis in NAFLD mice
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石斛是一种中国传统食药用植物，通过调节 NAFLD 小鼠的肠肝轴加速肝脏恢复
DOI：
10.1016/j.jff.2019.103458
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发表时间：
2019-10-01
影响因子：
5.6
通讯作者：
Chen, Su-Hong
中科院分区：
文献类型：
--
作者：
Lei, Shan-Shan;Li, Bo;Chen, Su-Hong
铁皮石斛（DOF）是一种传统的中国食用和生物利用植物。本研究的目的是探讨DOF超细粉（DOFP）对非酒精性脂肪性肝病（NAFLD）小鼠戒除高糖高脂（HSHF）饮食后的保肝作用及其潜在分子机制，这与NAFLD的临床治疗相关。我们的结果显示，停止HSHF饮食3周后，模型小鼠的血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平没有显着升高，但肝脏病变严重。 DOFP 调节肠道微生物群，防止模型小鼠肝脏中的脂质沉积和炎症病变。我们的研究结果表明，DOFP 可能通过抑制 LPS-TLR4 相关炎症介质激活来调节肠肝轴异常，并随后加速 NAFLD 小鼠的肝脏恢复。
Dendrobii Officinalis (DOF) is a Traditional Chinese edible and bioavailable plant. The aim of this study was to investigate the hepatoprotective effects of DOF ultrafine powder (DOFP) and its underlying molecular mechanisms in nonalcoholic fatty liver disease (NAFLD) mice after they were withdrawn from a high sugar and high fat (HSHF) diet, which is correlated with clinical treatment of NAFLD. Our results showed that there was no significant increase in the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), but liver lesions were severe in model mice after withdrawing from the HSHF diet for 3 weeks. DOFP regulated the gut microflora and prevented lipid deposition and inflammatory lesions in the livers of model mice. Our findings revealed that it is likely that DOFP modulated abnormalities of the gut-liver axis, by inhibiting LPS-TLR4-associated inflammatory mediator activation, and subsequently accelerated liver recovery in NAFLD mice.