Risk factors for goiter in a previously iodine-deficient region.
Risk factors for goiter in a previously iodine-deficient region.
复制标题
先前缺碘地区甲状腺肿的危险因素。
DOI：
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发表时间：
2005
影响因子：
1.8
通讯作者：
W. Meng
中科院分区：
文献类型：
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作者：
H. Völzke;C. Schwahn;Thomas Kohlmann;A. Kramer;D. Robinson;Ulrich John;W. Meng
目的
以前缺碘地区关于甲状腺肿的性别特异性风险因素及其协同作用的信息很少。本研究的目的是调查这种性别特异性的风险因素及其相互作用在一个大的人口为基础的样本。
方法和结果
波美拉尼亚健康研究（SHIP）包括4310名随机选择的参与者，年龄在20 - 79岁之间。SHIP是在先前碘缺乏的区域进行的。分析了3915名没有已知甲状腺疾病的参与者的数据。甲状腺肿大由甲状腺超声确定。社会人口学特征、吸烟和饮酒习惯、婚姻状况、教育水平、尿硫氰酸盐浓度，特别是女性、产次和既往或当前使用口服避孕药和激素替代疗法，被认为是多变量统计检验的候选风险因素。只有两个变量，高龄和当前吸烟，与两种性别甲状腺肿风险增加独立相关。分析进一步揭示了甲状腺肿的特定危险因素，这些因素在男性、绝经前和绝经后女性中存在差异。
结论
我们的结论是，除了以前的碘缺乏症，甲状腺肿的其他危险因素存在不同的性别。在可避免的风险因素中，目前吸烟与男性和女性甲状腺肿的风险密切相关。这些发现应该影响旨在预防甲状腺疾病的活动。
OBJECTIVE
Little information exists from formerly iodine-deficient areas regarding gender-specific risk factors for goiter and their synergisms. The aim of the present study was to investigate such gender-specific risk factors and their interactions in a large population-based sample.
METHODS AND RESULTS
The Study of Health in Pomerania (SHIP) comprised 4310 randomly selected participants, aged 20 - 79 years. SHIP was performed in a previously iodine-deficient region. Data from 3915 participants with no known thyroid disorders were analyzed. Goiter was determined by thyroid ultrasound. Sociodemographic characteristics, smoking and alcohol drinking habits, marital status, education level, urine thiocyanate concentrations, and specifically in women, parity and previous or current use of oral contraceptives and hormone replacement therapy, were considered as candidate risk factors for multivariable statistical tests. Only two variables, an advanced age and current smoking, were independently associated with an increased risk for goiter in both genders. Analyses further revealed specific risk factor profiles for goiter which were different among men, pre- and postmenopausal women.
CONCLUSION
We conclude that besides previous iodine deficiency, other risk factors for goiter exist which differ between gender. Among the avoidable risk factors, current smoking was strongly associated with the risk of goiter in men and women. These findings should influence activities which are intended to prevent thyroid disease.