Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats
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DOI：
10.1007/s00213-019-05333-w
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发表时间：
2019-08-01
影响因子：
3.4
通讯作者：
Rygula, Rafal
中科院分区：
文献类型：
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作者：
Noworyta-Sokolowska, Karolina;Kozub, Anna;Rygula, Rafal
根据心理学理论，认知扭曲在情绪障碍的病因和复发中起着关键作用。虽然临床证据抑郁症和改变敏感性的表现反馈的共存是相对一致的，我们仍然不知道是否增加或减少的敏感性，积极或消极的反馈是与健康受试者的“亲抑郁”的配置文件。目的我们的研究旨在回答这个问题，在这里，我们提出了朝着这个方向迈出的第一步。方法采用大鼠的概率反向学习（PRL）范式，评价负反馈和正反馈敏感性对情绪障碍相关认知过程的影响，如渐进比率强化计划（PRSR）范式中的动机、蔗糖偏好（SP）测试中的享乐状态、旷场（OF）测试中的运动和探索活动，和焦虑在光/暗盒（LDB）测试。结果本研究结果首次证实了啮齿类动物对负反馈和正反馈的敏感性可以被认为是一种稳定而持久的行为特征。重要的是，我们还表明，这些特质是相互独立的，并且对正反馈的特质敏感性与PRL测试中的认知灵活性相关。计算建模结果还显示，在被归类为对正反馈敏感的动物中，积极和消极奖励预测错误的alpha学习率高于被归类为不敏感的动物。我们没有观察到统计学上显着的负或正反馈的敏感性和参数测量的PRSR，SP，OF或LDB测试之间的相互作用。结论进一步研究抑郁症的动物模型的基础上，慢性应激应揭示是否反馈的敏感性是一个潜在的特质，当相互作用的压力生活事件，可以产生相关的抑郁症状的大鼠。
Rationale According to psychological theories, cognitive distortions play a pivotal role in the aetiology and recurrence of mood disorders. Although clinical evidence for the coexistence of depression and altered sensitivity to performance feedback is relatively coherent, we still do not know whether increased or decreased sensitivity to positive or negative feedback is associated with 'pro-depressive' profile in healthy subjects. Objective Our research has been designed to answer this question, and here, we present the first steps in that direction. Methods Using a rat version of the probabilistic reversal-learning (PRL) paradigm, we evaluated how sensitivity to negative and positive feedback influences other cognitive processes associated with mood disorders, such as motivation in the progressive ratio schedule of reinforcement (PRSR) paradigm, hedonic status in the sucrose preference (SP) test, locomotor and exploratory activity in the open field (OF) test, and anxiety in the light/dark box (LDB) test. Results The results of our study demonstrated for the first time that in rodents, sensitivity to negative and positive feedback could be considered a stable and enduring behavioural trait. Importantly, we also showed that these traits are independent of each other and that trait sensitivity to positive feedback is associated with cognitive flexibility in the PRL test. The computational modelling results also revealed that in animals classified as sensitive to positive feedback, the alpha learning rates for both positive and negative reward prediction errors were higher than those in animals classified as insensitive. We observed no statistically significant interactions between sensitivity to negative or positive feedback and the parameters measured in the PRSR, SP, OF or LDB tests. Conclusions Further studies using animal models of depression based on chronic stress should reveal whether sensitivity to feedback is a latent trait that when interacts with stressful life events, could produce correlates of depressive symptoms in rats.