Protective Effects of Mentha haplocalyx Ethanol Extract (MH) in a Mouse Model of Allergic Asthma
Protective Effects of Mentha haplocalyx Ethanol Extract (MH) in a Mouse Model of Allergic Asthma
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DOI：
10.1002/ptr.3341
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发表时间：
2011-06-01
影响因子：
7.2
通讯作者：
Shin, Hyeun-Kyoo
中科院分区：
文献类型：
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作者：
Lee, Mee-Young;Lee, Jin-Ah;Shin, Hyeun-Kyoo
薄荷是传统东方医学中常用的草药，具有多种已知的药理特性。然而，薄荷乙醇提取物 (MH) 对哮喘模型中气道炎症的保护作用及其相关机制此前均未有报道。在本研究中，使用卵清蛋白 (OVA) 诱导的过敏性哮喘小鼠模型来研究 MH 是否通过调节气道炎症来有效对抗该疾病。 MH 治疗显着抑制支气管肺泡灌洗液 (BALF) 和肺组织中免疫球蛋白 (Ig) E 和辅助 T 2 (Th2) 型细胞因子（例如 IL-4 和 IL-5）的增加。与 OVA 诱导组中观察到的浸润相比，接受 MH 治疗的小鼠气道炎症细胞浸润得到有效缓解。这些数据表明细胞因子水平降低是入侵白细胞数量减少的结果。此外，MH 处理还减少了 BALF 中活性氧 (ROS) 的产生。综上所述，这些发现表明 MH 的给药可能在炎症性疾病的治疗中具有潜在的治疗价值。版权所有 (C) 2010 约翰·威利父子有限公司
Mentha haplocalyx Briq., a commonly used herb in traditional Oriental medicine, has a variety of known pharmacological properties. However, neither the protective effects of Mentha haplocalyx ethanol extract (MH) against inflammation of the airway in an asthmatic model nor the mechanisms involved, have previously been reported. In the present study, an ovalbumin (OVA)-induced mouse model of allergic asthma was used to investigate whether MH was effective against the disease through regulation of airway inflammation. The MH treatment significantly inhibited increases in immunoglobulin (Ig) E and T-helper 2 (Th2)-type cytokines such as IL-4 and IL-5 in bronchoalveolar lavage fluid (BALF) and lung tissue. Inflammatory cell infiltration of the airway in mice treated with MH was effectively alleviated when compared with infiltration seen in the OVA-induced group. These data indicated that decreased cytokine levels are the result of the decreased number of invaded leukocytes. Also, the generation of reactive oxygen species (ROS) in BALF was diminished by MH treatment. Taken together, these findings indicate that the administration of MH may have potential therapeutic value in the treatment of inflammatory disease. Copyright (C) 2010 John Wiley & Sons, Ltd.