Prevention of Visual Stress and Migraine With Precision Spectral Filters.
Prevention of Visual Stress and Migraine With Precision Spectral Filters.
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使用精密光谱滤波器预防视觉压力和偏头痛。
DOI：
10.1002/ddr.20216
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发表时间：
2007
影响因子：
3.8
通讯作者：
Cao,Yue
中科院分区：
文献类型：
--
作者：
Wilkins,Arnold;Huang,Jie;Cao,Yue
患有偏头痛的人，特别是有视觉先兆的偏头痛(MWA)，容易受到生理上强烈的视觉刺激，并发现它们令人厌恶。包括强光和某些视觉模式在内的强烈刺激会产生不适和知觉错觉，并可能引发偏头痛发作。据报道，大多数偏头痛患者和经常头痛的人会出现知觉错觉和视觉不适。这些现象表明，视觉刺激和随之而来的视觉皮质活动有助于触发一些偏头痛发作。MWA患者的知觉错觉被发现与视皮层的过度激活有关。这种过度的大脑皮层活动称为视觉压力。偏头痛患者的大脑皮质通常被认为是过度兴奋的，这种过度兴奋可能是视觉压力的潜在机制。有人假设，视觉压力是由于对强烈的生理感觉刺激，特别是但不完全是视觉刺激而产生的神经(超神经)活动过大造成的。强烈的生理视觉输入可能导致兴奋通过过度兴奋的皮质传播，导致神经元不适当地放电，从而导致知觉错觉和扭曲，并可能促进偏头痛发作。在过去的10年里，使用彩色滤镜来处理文本的知觉扭曲在英国的许多学校已经变得很常见。几项研究报告了精密光谱滤光片(PSF)在预防偏头痛方面的有效性。一项初步研究揭示了PSF对一名MWA患者视觉皮质活动的抑制作用，这表明可能正是这种皮质激活的减少导致了PSF受益者偏头痛发作频率的减少。PSF为偏头痛的预防治疗提供了一种可能的新方法。它们是安全的，没有副作用，而且便宜。毒品开发中心68：469-475,2007。©2008 Wiley-Liss，Inc.
Individuals who suffer migraine, particularly migraine with visual aura (MwA), are susceptible to physiologically strong visual stimuli and find them aversive. Strong stimuli including bright light and certain visual patterns produce discomfort and perceptual illusions and can trigger migraine attacks. Perceptual illusions and visual discomfort are reported by most migraine sufferers and those with frequent headaches. These phenomena suggest that visual stimulation and consequent visual cortical activity contribute to the triggering of some migraine attacks. Perceptual illusions in MwA patients were found to be associated with hyper‐activation in visual cortex. This excessive cortical activity is called visual stress. The cortex is generally hypothesized to be hyperexcitable in migraine, and this hyperexcitability could be the underlying mechanism of visual stress. It is hypothesized that visual stress results from too great a neural (hyperneural) activity in response to strong physiological sensory stimulation, particularly, but not exclusively, visual. A strong physiological visual input may cause a spread of excitation through hyperexcitable cortex, leading to neurons firing inappropriately and thereby resulting in perceptual illusions and distortions, and possibly promoting a migraine attack. Over the last 10 years, the use of colored filters to treat perceptual distortion of text has become common in many schools in Britain. The efficacy of precision spectral filters (PSF) in preventing migraine headache has been reported in several studies. One preliminary study revealed the suppressing effect of the PSF on visual cortical activity in a MwA patient, suggesting that it might be this reduction in cortical activation that is responsible for the reduction of the frequency of migraine attacks in those who benefited from the PSF. PSF offer a possible new prophylactic therapy for migraine. They are safe, free of side effects, and inexpensive. Drug Dev Res 68:469–475, 2007. © 2008 Wiley‐Liss, Inc.