Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas
Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas
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DOI：
10.1007/s11060-013-1132-4
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发表时间：
2013-07-01
影响因子：
3.9
通讯作者：
Klein, M.
中科院分区：
文献类型：
--
作者：
van Nieuwenhuizen, D.;Ambachtsheer, N.;Klein, M.
关于脑膜瘤患者神经外科手术后的神经认知结果和健康相关生活质量（HRQOL）的数据很少，而对于未经治疗的稳定病变患者的神经认知功能和HRQOL的了解更少。本研究旨在量化未接受手术和/或放疗的疑似WHO I级脑膜瘤患者的神经认知缺陷和HRQOL的性质和程度，并将结果与健康对照组进行比较。采用标准化成套测验对21例影像学上疑似WHO I级脑膜瘤患者的神经认知功能进行了评估。使用MOS SF-36问卷评估HRQOL。这些患者与21名健康对照者在年龄、性别和教育程度上相匹配。一方面确定神经认知功能与HRQOL和肿瘤特征之间的关系。与健康对照组相比，脑膜瘤患者的心理速度（p = 0.011）和工作记忆容量（p = 0.034）较低，而且自我感知的一般健康和活力水平较低。未治疗患者的神经认知功能与肿瘤体积、水肿或肿瘤偏侧无关。心理速度和工作记忆与HRQOL之间无相关性。未经治疗的脑膜瘤稳定病变患者的神经认知功能和HRQOL有限。在决定治疗策略时，应考虑到这些功能下降，并与患者沟通。
Few data are available concerning the neurocognitive outcome and health-related quality of life (HRQOL) following neurosurgery in meningioma patients, and even less is known about neurocognitive functioning and HRQOL in untreated patients with stable lesions. The present study aims at quantifying the nature and extent of neurocognitive deficits and HRQOL in suspected WHO grade I meningioma patients who have not received surgery and/or radiotherapy and compare outcome to that of healthy controls. Neurocognitive functioning was assessed by using a standardized test battery in 21 radiologically suspected WHO grade I meningioma patients with a wait-and-scan approach. HRQOL was assessed with the MOS SF-36 questionnaire. These patients were matched for age, sex, and education with 21 healthy controls. Associations between neurocognitive functioning on the one hand and HRQOL and tumor characteristics on the other were determined. Compared to healthy controls, meningioma patients had lower psychomotor speed (p = 0.011) and working memory capacity (p = 0.034) and furthermore attained lower levels of self-perceived general health and vitality. Neurocognitive functioning in untreated patients was not related to tumor volume, edema or tumor lateralization. No correlations were found between psychomotor speed or working memory and HRQOL. Untreated meningioma patients with stable lesions have limitations in neurocognitive functioning and HRQOL. In deciding upon a treatment strategy these reductions in functioning should be taken into consideration and communicated with the patient.